Interleukin 6 - Wikipedia
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
IL-6 in Inflammation, Immunity, and Disease - PMC - PubMed …
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is ...
Interleukin-6: A Masterplayer in the Cytokine Network - PubMed
Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.
Interleukin-6 cytokine: An overview of the immune regulation, …
2022年10月1日 · Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending on the immune response context.
IL-6: A New Era for the Treatment of Autoimmune Inflammatory …
In this chapter, we will highlight the pathological role of IL-6 in autoimmune inflammatory diseases, offer perspectives on the future of IL-6 blockade therapy, and discuss the mechanisms potentially responsible for deregulated IL-6 overexpression.
Interleukin-6 cytokine: An overview of the immune regulation, …
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending on the immune response context. Macrophages are among several cells that secrete IL-6, which they express upon activation by antigens, subsequently …
Interleukin 6: at the interface of human health and disease
2023年9月27日 · IL-6 expression is mainly activated by interleukin 1 β (IL-1β) and tumor necrosis factor-alpha (TNFα); however, there are also other ways to promote its synthesis such as Toll-like receptor activation (TLRs), prostaglandins, adipokines, stress response, and other cytokines .
IL6 Gene - GeneCards | IL6 Protein | IL6 Antibody
2024年12月9日 · antibodies-online: Show 259 available IL-6 Proteins ranked by validation data; Compare Top IL-6 Proteins
A panoramic review of IL-6: Structure, pathophysiological roles …
2020年3月1日 · Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its receptor IL-6R, and glycoprotein 130 (IL-6/IL-6R/gp130).
Role of Interleukin-6 in Vascular Health and Disease - PMC
IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate immune response by ...