Imidazole - Wikipedia
网页Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, that stimulates the central nervous system .
咪唑 - 维基百科，自由的百科全书
网页咪唑的 酰基化 反应一般也在N-3上发生，但由于酰基是 吸电子基，故反应能控制在一元酰基化阶段，产物是 N -酰基咪唑。. 咪唑的活泼氢可以分解 格氏试剂，生成咪唑的 N -镁盐，经异构化后得到C-2取代的咪唑。. 后者用 碘甲烷 处理，可以生成1,2-二甲基咪唑 ...
Recent advances in the synthesis of imidazoles - RSC Publishing
网页2020年2月17日 · Imidazoles are an important heterocyclic structural motif in functional molecules and are utilized in a diverse range of applications. 1,2 Despite recent advances, the development of novel methods for the regiocontrolled synthesis of substituted imidazoles is of strategic importance.
Imidazole: Synthesis, Functionalization and Physicochemical …
网页2023年1月13日 · Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature provides much information about the synthesis, functionalization, physicochemical characteristics and biological role of imidazole.
Recent advances in the synthesis of imidazoles - RSC Publishing
网页2020年5月18日 · The review highlights the recent advances (2018-present) in the regiocontrolled synthesis of substituted imidazoles. These heterocycles are key components to functional molecules that are used in a variety of everyday applications.
Imidazoles as Potential Anticancer Agents: An Update on Recent …
网页2021年7月11日 · This review is intended to provide an overview of recent advances in imidazole-based anticancer drug discovery and development, as well as inspire the design and synthesis of new anticancer molecules. Keywords: imidazole, benzimidazole, purine, anticancer, antimicrotubule, kinase inhibitor. 1. Introduction.
Imidazole as a Promising Medicinal Scaffold: Current Status and …
网页2021年7月29日 · Various imidazole-containing compounds have been tested for their medical usefulness in clinical trials for several disease conditions. The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of imidazole-derived compounds for treating incurable diseases.
Imidazole: Uses, Interactions, Mechanism of Action - DrugBank …
网页2005年6月13日 · Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Imidazole: Having Versatile Biological Activities - Verma - 2013 ...
网页2013年10月31日 · Imidazoles are well-known heterocyclic compounds which are common and have an important feature of a variety of medicinal agents. On the basis of various literature surveys, imidazole derivatives show various pharmacological activities: (i) antibacterial activity; (ii) anticancer activity; (iii) antitubercular activity; (iv) antifungal; (v)
Imidazole - an overview | ScienceDirect Topics
网页Imidazoles, benzimidazoles, imidazolines, imidazolidines, and related carbenes are classes of heterocyclic compounds possessing unique chemical and physical properties. Tremendous advances in imidazole chemistry have been made in the decade since 1995, and are manifested in the large body of the literature related to imidazole and its analogs.