Lipid nanoparticles for mRNA delivery - Nature Reviews Materials
2021年8月10日 · In this Review, we briefly overview representative lipid nanoparticles used for mRNA delivery and describe key steps in the preclinical development of lipid nanoparticle–mRNA...
Lipid nanoparticles for mRNA delivery - PubMed
Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle-mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics.
Artificial intelligence-driven rational design of ionizable lipids for ...
2024年12月30日 · The success of mRNA vaccines against COVID-19 1,2 has firmly established lipid nanoparticles (LNPs) as the foremost method for mRNA delivery. Additionally, the growing adoption of LNPs as a ...
Lipid nanoparticles for mRNA delivery - PMC - PubMed Central …
Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle–mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics.
Chemistry of Lipid Nanoparticles for RNA Delivery
2021年12月1日 · Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a homogeneous lipid core. These vesicles are widely used in small-molecule drug and nucleic acid delivery and recently gained much attention because of their remarkable success as a delivery platform for COVID-19 mRNA vaccines.
Biomimetic noncationic lipid nanoparticles for mRNA delivery
2023年12月11日 · A noncationic lipid nanoparticle was constructed for mRNA delivery with simple, convenient, and repeatable preparation technology, negligible inflammatory and cytotoxicity side effects, high gene transfection efficiency, and spleen-targeting delivery to induce immunity for disease treatments.
Simplified Lipid Nanoparticles for Tissue‐ And Cell‐Targeted mRNA ...
In this study, a platform is developed for selective mRNA delivery to desired cells within tissues by combining lipid nanoparticle (LNP)-based targeted delivery with mRNA sequence-controlled expression. Through systematic optimization, a three-component LNP platform is developed, enabling targeted mRNA delivery to the lung, liver, and spleen.
Lipid nanoparticles: A delicate nucleic acid delivery system to be ...
Lipid nanoparticles (LNPs) are currently the only carriers approved for siRNA and mRNA delivery in the clinic. The success of LNPs relies on decades of iterative research to make them safe, stable and highly efficient for nucleic acids delivery in vivo.
Development of mRNA Lipid Nanoparticles: Targeting and …
Lipid nanoparticles (LNPs) have emerged as leading non-viral carriers for messenger RNA (mRNA) delivery in clinical applications. Overcoming challenges in safe and effective mRNA delivery to target tissues and cells, along with controlling release from the delivery vehicle, remains pivotal in mRNA-based therapies.
Nebulized Lipid Nanoparticles Based on Degradable Ionizable ...
1 天前 · As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles ...