The calcium sensitizer drug MCI-154 binds the structural C …
2018年11月1日 · Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac troponin C (cTnC). Surprisingly, however, it binds only to the structural C-terminal domain of cTnC (cCTnC), and not to the regulatory N-terminal domain (cNTnC) that determines the calcium sensitivity ...
The calcium sensitizer drug MCI-154 binds the structural C …
2018年11月1日 · The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac troponin C (cTnC).
MCI-154 Increases Ca2+ Sensitivity of Reconstituted Thin Filament ...
MCI-154 increased the threshold pCa value at which the reconstituted thin filament started to move on the myosin layer in a dose-dependent manner, demonstrating that the MCI-154 directly acts on the reconstituted thin filament to increase the sensitivity to Ca 2+.
MCI‐154: A Second Generation Ca2+ Sensitizer That Does
2006年6月7日 · MCI-154 (6-[4-(4'-pyridylamino)phenyl]-4,5-dihydro-3(2H)pyridazinone hydrochloride trihydrate) is a potent novel cardiotonic agent whose positive inotropism is shown to be mainly...
MCI-154, a Ca2+ sensitizer, increases survival in cardiomyopathic ...
1999年5月14日 · MCI-154, 6- [4- (4′-pyridylamino)phenyl]-4,5-dihydro-3 (2 H )-pyridazinone hydrochloride trihydrate, is a positive inotropic agent that has peripheral vasodilator properties ( Narimatsu et al., 1987 ).
MCI-154, a Ca2+ sensitizer, increases survival in cardiomyopathic ...
1999年5月14日 · MCI-154, 6-[4-(4′-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate, is a positive inotropic agent that has peripheral vasodilator properties (Narimatsu et al., 1987).
MCI-154, a cardiac Ca2+ sensitizer, reverses the depression in ... - PubMed
In the present study we investigated the effects of MCI-154, a Ca2+ sensitizer that can enhance crossbridge interaction, on the decline in maximal Ca2+-activated force by Pi or acidic pH in skinned fiber bundles of guinea pig hearts.
MCI-154, a Ca2+ sensitizer, increases survival in cardiomyopathic ...
1999年5月14日 · To assess the long-term efficacy of a Ca2+ sensitizer MCI-154, 6-[4-(4'-pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate, on chronic heart failure, we studied the effects of the agent on the life span of cardiomyopathic hamsters of the BIO-14.6 strain. At approximately 15 …
Mci-154, a Cardiac Ca2+ Sensitizer, Reverses the Depression
MCI-154 inhibited the rightward shift of the pCa–tension relationships, with a marked decrease of maximal force produced by 20 mM Pior acidic pH (decrease in pH from 7.0 to 6.6). MCI-154 also improved the decline in maximal Ca 2+-activated
(PDF) The calcium sensitizer drug MCI-154 binds the structural C ...
2018年11月1日 · The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the...