List of Common Quinolones + Uses, Types & Side Effects - Drugs.com
2024年2月15日 · Quinolones are a type of antibiotic. Antibiotics kill or inhibit the growth of bacteria. Nalidixic acid was the first quinolone discovered, but it has since been discontinued. There are five different quinolone classes. One of the classes, called fluoroquinolones, was derived from quinolones by adding a fluorine atom to nalidixic acid.
Quinolone antibiotic - Wikipedia
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. [2]
Quinolones - StatPearls - NCBI Bookshelf
2023年5月22日 · Quinolones are bactericidal antibiotics that directly kill bacterial cells. They act on bacterial type II topoisomerases, DNA gyrase, and topoisomerase IV, inhibiting their function and converting them into toxic enzymes that produce permanent double-stranded breaks in the bacterial chromosome.
Quinolones: A Comprehensive Review - AAFP
2002年2月1日 · Most quinolones have excellent oral bioavailability, with serum drug concentrations equivalent to intravenous administration. Quinolones have few adverse effects, most notably nausea, headache,...
Quinolones: Uses, common brands, and safety info - SingleCare
2022年3月28日 · Quinolones are a type of antibiotic that inhibit bacterial growth in serious, complicated infections. Learn more about quinolone uses and safety here.
Quinolones | Current Medical Diagnosis & Treatment 2024 ...
The quinolones are synthetic analogs of nalidixic acid with a broad spectrum of activity against many bacteria. The mode of action of all quinolones involves inhibition of bacterial DNA synthesis by blocking the enzyme DNA gyrase.
Quinolones: from antibiotics to autoinducers - PMC
Quinolones are molecules structurally derived from the heterobicyclic aromatic compound quinoline, the name of which originated from the oily substance obtained after the alkaline distillation of quinine (Gerhardt, 1842).
Mechanism of Quinolone Action and Resistance - PMC
Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome. This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quinolone action against their enzyme targets.
Biological Effects of Quinolones: A Family of Broad-Spectrum ...
Discovered as a by-product, in the search for improved synthesis of the anti-malarial chloroquine, quinolones are one of the most important families of antimicrobial agents, extensively used to combat bacterial infections.
Quinolone antibiotics - PMC - National Center for Biotechnology …
Quinolones are broad-spectrum antibiotics that are active against both Gram-positive and Gram-negative bacteria, including mycobacteria, and anaerobes. They exert their actions by inhibiting bacterial nucleic acid synthesis through disrupting the enzymes topoisomerase IV and DNA gyrase, and by causing breakage of bacterial chromosomes.