R406 | Syk/FLT3 抑制剂 | MCE - MCE-生物活性分子大师
R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC 50 of 41 nM, measured at an ATP concentration corresponding to its K m value. R406 reduces immune complex-mediated inflammation. R406 also inhibits Lyn (IC 50 =63 nM) and Lck (IC 50 =37 nM).
R406 | 购买Syk 抑制剂 - Selleck - Selleck中国
R406(R406 besylate) 是一种有效的 Syk 抑制剂，无细胞试验中IC50为41 nM，对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。R406 可诱导凋亡。 R406 可诱导凋亡。
R406.1 Scope. This section establishes additional energy efficiency requirements for all new construction covered by this code including additions subject to Section R502 and change of occupancy or use subject to Section R505 unless specifically exempted in Section R406. Credits from both Sections R406.2 and R406.3 are required.
Advancing energy codes in Washington are leading builders, designers and tradespeople to evaluate new designs and strategies. This “Cookbook” provides a collection of “Recipes” for single-family new construction to comply with the 2021 Washington State Residential Energy Code (WSEC-R) Section R406: Additional Energy Eficiency Requirements.
R406.1 Scope. This section establishes additional energy efficiency requirements for all new construction covered by this code, including additions subject to Section R502 and change of occupancy or use
R406, an orally available spleen tyrosine kinase inhibitor blocks fc ...
Here we show that the primary target for R406 is the spleen tyrosine kinase (Syk), which plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells.
R406 besylate | Syk inhibitor - Active metabolite of Fostamatinib ...
R406 (the active metabolite of Fostamatinib) is a specific, ATP-competitive inhibitor of spleen tyrosine kinase (Syk), which plays a key role in innate and adaptive immunity. Inhibition of Syk with R406 selectively abrogates inflammasome activation by …
R406 (free base) | 购买Syk 抑制剂 - Selleck - Selleck中国
R406 (free base) 是一种有效的 Syk 抑制剂，无细胞试验中 IC50 为41 nM，强效抑制Syk而不能抑制Lyn，对Flt3作用效果低5倍。 R406 (free base) 可触发凋亡。 Phase 1。 R406是ATP竞争性Syk抑制剂，K i 为30 nM。 在不同细胞中R406选择性抑制 Syk依赖的信号通路，EC50为33 nM 到171 nM,比作用于 Syk非依赖性通路效果高很多。 [1] R406作用于多种弥漫性巨大细胞淋巴瘤，抑制细胞增殖，EC50 为0.8 μM 到 8.1 μM。 1 μM 或 4 μM R406处理DLBCL细胞系，诱 …
R406(R-406) R406苯磺酸盐 Syk抑制剂|CAS 841290-81-1 - 翌圣生物
R406 (R-406) 苯磺酸盐 是一种 可 口服的 、 ATP竞争性Syk抑制剂，K i 为30 nM，IC 50 为41 nM 。 产品性质
Fostamatinib及其活性部分R406的临床药代动力学和 ... - X-MOL
由于r406是血液中的主要产物，本综述主要讨论r406的药代动力学和药效学。 它在肝脏中由细胞色素 3A4 和 UGT1A9 代谢，并在肠道微生物群厌氧修饰后主要在粪便中排泄。