Reovirus structure and infectious cycle. (A) Reovirus is a...
Reovirus is an unenveloped, double-stranded RNA virus that is tropic to the GBM cells. Reoviruses enter the tumor cells primarily through the ligated adhesion molecule A (JAM-A) …
Probing reovirus binding to living cells. a Schematic of reovirus ...
The initial attachment of reovirus to cells involves specific binding between the viral σ1 protein and the receptor, JAM-A. Cell-surface glycans serve as attachment factors, and virus binding...
Schematic of the reovirus virion. The outer capsid (blue) and core ...
We applied segment genotypes to determine reovirus genome constellations, and we propose implementation of an updated reovirus genome classification system that incorporates …
REOVIRUS RECEPTORS, CELL ENTRY, AND PROAPOPTOTIC …
In this chapter, we consider mechanisms of reovirus cell entry and describe our current understanding about how these entry events initiate proapoptotic signaling. Members of the …
From Touchdown to Transcription: The Reovirus Cell Entry Pathway
Reoviruses contain ten double-stranded RNA gene segments enclosed in two concentric protein shells, outer capsid and core. These viruses serve as a versatile experimental system for …
Function, Architecture, and Biogenesis of Reovirus Replication ...
2019年3月21日 · Reoviruses are common pathogens of mammals that have been linked to celiac disease and show promise for oncolytic applications. These viruses form nonenveloped, …
Function, Architecture, and Biogenesis of Reovirus Replication ...
In a variety of cell types, reovirus inclusions can be detected by light microscopy as early as 4 h post-infection. VIs contain several types of filaments, viral proteins, ssRNAs, dsRNAs, and …
Reovirus Activated Cell Death Pathways - PMC - National Center …
2022年5月27日 · ReoV manifests its oncolytic effects in large part by infecting tumor cells and activating programmed cell death pathways (PCDs). It was previously believed that apoptosis …
Reovirus structure and replication. (A) Reovirus outer capsid …
Cell attachment is mediated through (1a) sialic acid binding, (1b) JAM-A association, and (1c) integrin binding; (2) Reovirus is internalized through endocytosis.
Reovirus Activated Cell Death Pathways - PubMed
2022年5月27日 · In this review, we summarize our current understanding of the ReoV replication cycle, the known and potential mechanisms by which ReoV induces PCD, and discuss the …