可溶性白细胞介素-2受体 - 百度百科
可溶性白细胞介素-2受体(soluble interleukin-2 receptor，SIL-2R)是一种复合性粘蛋白，同时具有与抗Tac单抗和白细胞介素-2结合的信息，与白细胞介素-2结合不需任何辅助因子，可溶性白细胞介素-2受体是一种重要的免疫抑制剂，可中和活化T细胞周围的白细胞介素-2、减弱 ...
SIL-2R - 百度百科
可溶性白细胞介素-2 受体（soluble interleukin-2 receptor，可溶性白细胞介素2受体）是一种复合性粘蛋白，同时具有与抗Tac单抗和白细胞介素-2结合的信息，与白细胞介素-2结合不需任何辅助因子，可溶性白细胞介素-2受体是一种重要的免疫抑制剂，可中和活化T细胞 ...
Clinical significance of soluble interleukin-2 receptor ... - PubMed
A soluble form of the interleukin-2 receptor (sIL-2R) is secreted upon T-cell activation. Increased blood levels of sIL-2R occur in a variety of immunological diseases. Although the biological function of sIL-2R is incompletely understood, both in health and disease, sIL-2R serum measurements are co …
Why measure soluble interleukin-2 receptor levels? - News-Medical.net
2024年5月6日 · The measurement of soluble interleukin-2 receptor (sIL-2R) levels in serum or plasma in adults has become a valuable tool for clinicians to assess immune function in vivo as part of the...
Soluble interleukin-2 receptor is a sensitive diagnostic test in …
2017年12月6日 · Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults. We conducted a single-center retrospective study of 78 consecutive adults who had sIL-2r measured for suspected HLH.
On the Role of sIL-2R Measurements in Rheumatoid Arthritis and …
2005年8月8日 · Several lines of evidence indicate sIL-2R measurements to be useful in determining disease progress and prognosis. This review summarizes current knowledge on the sIL-2R behavior in RA and solid cancers of varied etiology.
The IL-2 – IL-2 receptor pathway in health and ... - ScienceDirect
2020年9月1日 · Measuring sIL-2R in clinical practice may be relevant for diagnosis, prognosis and/or monitoring immune-mediated diseases. sIL-2R may further develop as an important biomarker in precision medicine. The interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance.
Biological role of the soluble interleukin-2 receptor in sarcoidosis
Several potential mechanisms of sIL-2R’s biological functions include IL-2 sequestration, prolonging IL-2 half-life, preventing activation of resting T cells or increasing affinity of IL-2Rβ for IL-2. The most likely function of sIL-2R is to modify IL-2 signaling.
Serum soluble interleukin-2 receptor levels for screening for …
Soluble IL-2 receptor α (sIL2R) is detected in the serum of healthy individuals and increases in association with various types of inflammation or neoplasms (1 – 3). However, the mechanism and functional significance of elevated sIL2R levels for …
Performance of serum soluble interleukin-2 receptor as a ... - Nature
2023年11月1日 · Serum sIL-2R showed high performance as an adjunctive diagnostic marker for lymphoma, particularly among febrile patients. Different cutoff values should be used for patients with and without...