Spermine - Wikipedia
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.
The function of spermine - PubMed
This review describes these alterations and focuses on the roles of spermine which may contribute to these phenotypes including reducing damage due to reactive oxygen species, protection from stress, permitting correct current flow through inwardly rectifying K(+) channels, controlling activity of brain glutamate receptors involved in learning ...
Spermine - an overview | ScienceDirect Topics
Spermine is an endogenous polyamine that is produced in increased amounts following ischemia due to the enhanced activity of ornithine decarboxylase. It has been found to have a potentiating effect on the activities of ASICs and exacerbates ischemic neuronal injury by sensitizing ASIC1a to acidosis.
The function of spermine - Pegg - 2014 - IUBMB Life - Wiley …
2014年1月6日 · Spermine is the most strongly basic polyamine and the great majority of the cellular spermine is bound to acidic sites on macromolecules. Release of spermine from these sites is likely to induce the polyamine back-conversion/catabolic pathways that generate spermidine (Fig. 1A).
Spermine: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Spermine is a spermidine-derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. Type Small Molecule Groups
Spermine | C10H26N4 | CID 1103 - PubChem
Spermine is a spermidine -derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. DrugBank.
The natural polyamine spermine functions directly as a free ... - PNAS
The polyamine spermine, which is normally found in millimolar concentrations in the nucleus, is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified.
Spermine - an overview | ScienceDirect Topics
Spermine, so named as a polyamine that was first discovered in semen, is present in seminal plasma at concentrations of 50–350 mg/dL and imparts a unique odor to semen. The prostate gland has the highest concentration of spermine in the human body and is the primary source of this polyamine in seminal plasma.
Spermine Synthesis Is Required for Normal Viability, Growth, …
Spermidine is essential for viability in eukaryotes but the importance of the longer polyamine spermine has not been established. Spermine is formed from spermidine by the action of spermine synthase, an aminopropyltransferase, whose gene (SpmS) is located on the X …
Spermine - NIST Chemistry WebBook
Spermine. Formula: C 10 H 26 N 4. Molecular weight: 202.3402. IUPAC Standard InChI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2. IUPAC Standard …
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