KCNK2 - Wikipedia
网页Potassium channel subfamily K member 2, also known as TREK-1, is a protein that in humans is encoded by the KCNK2 gene. [5][6][7] This gene encodes K 2P 2.1, a lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family.
Role of TREK-1 in Health and Disease, Focus on the Central …
网页2019年4月11日 · TREK-1 is multi-regulated by a variety of physical and chemical stimuli which makes it a very promising and challenging target in the treatment of several pathologies. It is mainly expressed in the brain but also in heart, smooth muscle cells, endocrine pancreas, and prostate.
Role of TREK-1 in Health and Disease, Focus on the Central ... - PubMed
网页2019年4月11日 · TREK-1 is the most studied background K 2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization. TREK-1 is multi-regulated by a variety of physical and chemical stimuli which makes it a very promising and challengi …
TREK-1, a K - National Center for Biotechnology Information
网页2004年7月7日 · TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. It is inhibited by neurotransmitters that produce an increase in intracellular cAMP and by those that activate the Gq protein pathway.
Tension activation of mechanosensitive two-pore domain K
网页2024年4月11日 · TRAAK, TREK-1, and TREK-2 are mechanosensitive two-pore domain K+ (K2P) channels that contribute to action potential propagation, sensory transduction, and muscle contraction.
TREK-1 null impairs neuronal excitability, synaptic plasticity, and ...
网页TREK-1, a two-pore-domain K + channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood.
The neuronal background K 2P channels: focus on TREK1
网页The Trek1−/− mutant mice are healthy, fertile and do not display any visible morphological difference. However, recent studies indicate a central role for TREK1 in anaesthesia, neuroprotection,...
TREK-1 in the heart: Potential physiological and …
网页2022年12月22日 · Improved understanding of the role of TREK-1 in the heart may help the development of promising treatments for challenging cardiac diseases. Keywords: K2P2.1; RVOT; TREK-1; atrial fibrillation; myocardial infarction.
TREK‐1 is a heat‐activated background K + channel
网页The expression of TREK‐1 in the small and medium size diameter DRG sensory neurons makes it a possible candidate for temperature sensing. Opening of TREK‐1 when warming up to 42°C will polarize cells and contributes to reduced discharge of action potentials.
TREK‐1, a K - The EMBO Journal
网页2004年6月3日 · Using mice with a disrupted TREK‐1 gene, we now show that TREK‐1 has an important role in neuroprotection against epilepsy and brain and spinal chord ischemia. Trek1 −/− mice display an increased sensitivity to ischemia and epilepsy.
跳至内容