Brodifacoum - an overview | ScienceDirect Topics
网页Brodifacoum is a rodenticide that interferes with the production of vitamin K-dependent coagulation factors, leading to prolonged periods of anticoagulation and increased bleeding time. Treatment involves replacing clotting factors and administering vitamin K. AI generated definition based on: Encyclopedia of Toxicology (Third Edition), 2014
Brodifacoum - an overview | ScienceDirect Topics
网页2015年4月2日 · Pure brodifacoum is an off-white to fawn-colored powder with a solubility of 6–20 g/L in acetone, 3 g/L in chloroform, 0.6–6 g/L in benzene, and less than 10 mg/L water. It is very stable in the environment with no loss after 30 days of exposure to direct sunlight (Chalermchaikit et al., 1993).
Brodifacoum poisoning: A clear and present danger to public …
网页2017年2月15日 · Amongst the superwarfarins typically incorporated into rodent bait, brodifacoum (BDF) is the most widely used. Poisoning by ingestion, inhalation or absorption through the skin of BDF shows no signs or symptoms in humans other than delayed (after several days) development of severe, long-lasting (up to months) bleeding events.
Brodifacoum poisoning: A clear and present danger to public …
网页2017年2月15日 · Amongst the superwarfarins typically incorporated into rodent bait, brodifacoum (BDF) is the most widely used. Poisoning by ingestion, inhalation or absorption through the skin of BDF shows no signs or symptoms in humans other than delayed (after several days) development of severe, long-lasting (up to months) bleeding events.
Brodifacoum - an overview | ScienceDirect Topics
网页Toxicokinetics. The metabolic fate of brodifacoum in humans is not well understood. Brodifacoum is much more lipid soluble than warfarin, resulting in a larger volume of distribution. There is extensive hepatic sequestration and prolonged high liver concentrations in the rat. Brodifacoum may also undergo enterohepatic recirculation in the rat.
Brodifacoum - an overview | ScienceDirect Topics
网页Brodifacoum was detected in the blood at a level of 0.002 ppm. The bird was treated with injectable and oral vitamin K 1 and transfused with 40 ml of whole blood and fully recovered (James et al., 1995). Absorption, Distribution, Metabolism, and Excretion. Brodifacoum is absorbed through the gastrointestinal tract. When orally administered to ...
Plasma metabolic profiling analysis of toxicity induced by …
网页2016年10月1日 · Brodifacoum poisoning was confirmed since all of the blood samples collected from treatment groups were tested positive for brodifacoum. The blood brodifacoum concentration in the low-dose, middle-dose, and high-dose groups were 0.6 ± 0.2 ng/mL, 3.7 ± 1.2 ng/mL, and 7.4 ± 2.6 ng/mL, respectively. Thus, the blood brodifacoum concentration was ...
Trace detection of bromadiolone and brodifacoum in biological …
网页2023年4月1日 · The widespread use of bromadiolone and brodifacoum poses a threat to public health and initiates poisoning incidents. Conventional colorimetric enzyme-linked immunosorbent assays (ELISAs) suffer from poor sensitivity, making it difficult to meet the trace detection of analytes.
Determination of bromadiolone and brodifacoum in human blood …
网页2012年10月10日 · The brodifacoum concentration was determined to be 20 ng/mL 16 days after the initial determination with a half-life of 15 days [8]. A woman who was admitted for a headache, loss of consciousness, and coagulopathy had an initial serum concentration of 93 ng/mL, with an estimated half-life of 30 days [25] .
Non-target species mortality and the measurement of …
网页2015年5月1日 · Brodifacoum 25W: Conservation was available to all target and many non-target organisms, and brodifacoum residues were detected in all non-target animal groups sampled. Residues in non-target animals could have arisen from non-target organisms feeding directly on bait or they were secondary consumers feeding …