Eotaxin - Wikipedia
Eotaxin is a special CC chemokine because it primarily attracts eosinophils. [2] By being a chemoattractant for eosinophils, eotaxin has a direct relationship with inflammation. This is because eosinophils are known to promote inflammation. In order to induce stimulation, eotaxin binds with the CCR-3 receptor.
Eotaxin - an overview | ScienceDirect Topics
Eotaxin is a small protein produced in the lungs of asthmatic patients that attracts eosinophils, a type of white blood cell, by interacting with a specific receptor on their surface. It plays a role in the recruitment of eosinophils to lung tissue, which is associated with the pathogenesis of asthma.
Eotaxin | An Essential Mediator of Eosinophil Trafficking into …
Eotaxin was distinguished from all other chemokines because it was found to be a potent eosinophil-selective chemoattractant having minimal activity on other leukocytes. Eotaxin was also identified as a potent activator of eosinophils capable of inducing superoxide generation and the release of granule proteins.
CCL-11 or Eotaxin-1: An Immune Marker for Ageing and …
Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions. Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper reviews the associations between CCL-11 and aging, neurodegenerative, neuroinflammatory and neuropsychiatric disorders.
Eotaxin - an overview | ScienceDirect Topics
Eotaxin-1 (CCL-11) is a potent eosinophil chemoattractant that is considered a major contributor to tissue eosinophilia. Elevated eotaxin-1 levels have been described in various pathologic conditions, ranging from airway inflammation, to Hodgkin lymphoma, obesity and …
Eotaxin - an overview | ScienceDirect Topics
Eotaxin, a chemokine for eosinophils, is elevated in adipose tissue and serum in obese humans and animal models (Vasudevan et al., 2006). This suggested an inflammatory activation of allergic innate immune responses with obesity.
From Allergy to Cancer—Clinical Usefulness of Eotaxins - PMC
Eotaxins are a potent stimulators of specific cell types. Eotaxin-1 is considered as a chemoattractant mainly for eosinophils, but also basophils, T helper 2 lymphocytes, thymocytes, macrophages, and mast cells.
Eotaxin: from an eosinophilic chemokine to a major regulator of ...
1999年11月1日 · Here, Jose Carlos Gutierrez-Ramos and colleagues review the chemotactic effects of eotaxin on eosinophils and T helper type 2 cells, its differentiation and migration effects on mast cells and its actions on progenitors and mature cells in the bone marrow.
Eotaxin is required for the baseline level of tissue eosinophils
1998年5月5日 · Eotaxin is an eosinophil-selective chemokine that is constitutively expressed in a variety of organs such as the intestine. Previous studies have demonstrated that the recruitment of eosinophils during inflammation is partially dependent on eotaxin, but the function of constitutive eotaxin during homeostasis has not been examined.
Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible …
CCL11 is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. Eotaxins may exert physiological and pathological functions in the central nerve system, and CCL11 may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells.