Osmolyte - Wikipedia
网页Osmolytes are low-molecular-weight organic compounds that influence the properties of biological fluids. Osmolytes are a class of organic molecules that play a significant role in regulating osmotic pressure and maintaining cellular homeostasis in various organisms, particularly in response to environmental stressors. [1]
Intracellular Organic Osmolytes: Function and Regulation - PMC
网页2008年3月3日 — In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines.
In situ analysis of osmolyte mechanisms of proteome thermal ...
网页2024年2月29日 — Organisms use organic molecules called osmolytes to adapt to environmental conditions. In vitro studies indicate that osmolytes thermally stabilize proteins, but mechanisms are controversial, and...
Osmolyte - an overview | ScienceDirect Topics
网页An osmolyte is a low molecular weight molecule found in the cytoplasm of organisms living in high salt environments. These molecules help regulate osmotic pressure without affecting protein function, and they contribute to enhancing protein stability.
Regulation of Cell Volume by Osmolytes | SpringerLink
网页2017年5月17日 — Osmolytes are small organic molecules dissolved in cellular and extracellular fluids of all forms of living organisms to maintain the cellular volume. However, in addition to their role in volume regulation, osmolytes do play a …
Naturally occurring organic osmolytes: From cell physiology to
网页2010年12月28日 — Osmolytes are naturally occurring organic compounds, which represent different chemical classes including amino acids, methylamines, and polyols. By accumulating high concentrations of osmolytes, organisms adapt to perturbations that can cause structural changes in their cellular proteins.
Osmolyte System and Its Biological Significance
网页2017年5月17日 — The quantum of a specific osmolyte present is dependent on compartmentalization of cell, organ, developmental stage, and surrounding conditions. A well-synchronized regulation of biosynthetic and catabolic pathways determines the process of accumulation and the mode of action of the osmolytes.
Osmolytes and Cell‐Volume Regulation ... - Wiley Online Library
网页2011年1月1日 — Abstract. The sections in this article are: 1 What Makes a Solute an Osmolyte? 2 The Basic Osmoregulatory Response: Conservation Paired with Change. 3 Osmolyte Taxonomy: Evolutionary Convergence and Conservation. 3.1 The Discovery of Organic Osmolytes. 3.2 Polyols and Sugars. 3.3 Free Amino Acids and Their Derivatives.
Protein-Osmolyte Interactions: Molecular Insights | SpringerLink
网页2017年5月17日 — Osmolytes, small molecular weight organic molecules, are capable of maintaining structural and functional integrity of macromolecules. It has been known that osmolytes help to protect functional integrity of proteins by increasing their thermodynamic stability and inducing folding of unstable or misfolded proteins.
Roles of osmolytes in protein folding and aggregation in cells and ...
网页2018年4月1日 — Osmolytes protect and stabilize proteins thermodynamically by regenerating native forms from unfolded states by interacting with protein surfaces. Additionally, the accumulation of heat shock proteins helps organisms with heat resistance by refolding denatured polypeptides and preventing protein aggregations [4, 5].