酞嗪 - 百度百科
酞嗪是一种杂环化合物，化学式为C₈H₆N₂，由1个苯环与1个哒嗪环稠合而成。 研究发现，酞嗪具有多种生理活性，如抗癌、抗菌、抗炎等。 合成具有新颖结构和较好生物活性的酞嗪化合物成为近年来的研究热点。
1 (2H)-Phthalazinone | C8H6N2O | CID 8394 - PubChem
1(2H)-Phthalazinone | C8H6N2O | CID 8394 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Phthalazin-1(2H)-one as a remarkable scaffold in drug discovery
2015年6月5日 · Phthalazin-1 (2H)-one (1), also called 2H-benzo [d]pyridazin-1-one, is a benzo-fused heterocycle that presents a 1,2-diazine ring with two adjacent nitrogen atoms exhibiting a tautomeric equilibrium in solution which has been the subject of many studies.
2,3-二氮杂萘酮 - 百度百科
2,3-二氮杂萘酮英文名称为1(2H)-Phthalazinone，中文别名有1-羟基酞嗪、1-(2H)-酞嗪酮、 2,3-杂氮萘酮 ，CAS号码为119-39-1，分子式为C8H6N2O，分子量是146.15，属于医药中间体，可作为 肼苯哒嗪 盐酸盐的中间体。
Recent advances in the synthesis of phthalazin-1(2H)-one core as a ...
2019年1月1日 · Phthalazin-1 (2H)-one is a diazaheterobicycle found in a wide variety of synthetic molecules relevant to several branches of chemistry, including medicinal chemistry. The versatility of phthalazinone core in drug discovery has promoted the search for new synthetic methods to get access to differently substituted and functionalized derivatives.
phthalazin-1(2H)-one - an overview | ScienceDirect Topics
Phthalazin-1 (2H)-one is a diazaheterobicycle found in a wide variety of synthetic molecules relevant to several branches of chemistry, including medicinal chemistry. The versatility of phthalazinone core in drug discovery has promoted the search for new synthetic methods to get access to differently substituted and functionalized derivatives.
Phthalazinone Scaffold: Emerging Tool in the Development of …
It describes mechanistic insights into the anticancer properties of phthalazinone derivatives and also highlights various simple and economical techniques for the synthesis of phthalazinones. Keywords: Cancer; DNA topoisomerases inhibitors; P-glycoprotein inhibitors; PARP inhibitor; VEGFR and EGFR inhibitors; aurora kinase inhibitors; hedgehog ...
Phthalazinone Pyrazoles as Potent, Selective, and Orally …
We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability ...
Synthesis and Biological Evaluation of New Phthalazinone
Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, (1) H NMR, (13) C NMR spectroscopy, and MS.
Phthalazinone, 21 | C36H48FN3O5 | CID 44123741 - PubChem
2021年5月7日 · Phthalazinone, 21 | C36H48FN3O5 | CID 44123741 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.