List of Common Quinolones + Uses, Types & Side Effects - Drugs.com
2024年2月15日 · Compare quinolones and fluoroquinolones (fluoroquinolones). View important safety information, ratings, user reviews, popularity and more.
Quinolone antibiotic - Wikipedia
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] . They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. [2]
Quinolones - StatPearls - NCBI Bookshelf
2023年5月22日 · Quinolones are bactericidal antibiotics that directly kill bacterial cells. They act on bacterial type II topoisomerases, DNA gyrase, and topoisomerase IV, inhibiting their function and converting them into toxic enzymes that produce permanent double-stranded breaks in the bacterial chromosome.
Quinolones: Uses, common brands, and safety info - SingleCare
2022年3月28日 · Quinolones are a type of antibiotic used to help fight against various bacteria. Because of their inhibition of several different types of microorganisms, they are considered broad-spectrum antibiotics.
Quinolones: A Comprehensive Review - AAFP
2002年2月1日 · Quinolones provide exceptional coverage against atypical pathogens when infection with these organisms is suspected in patients with community-acquired pneumonia.
Quinolones: from antibiotics to autoinducers - PMC - PubMed …
Quinolones are molecules structurally derived from the heterobicyclic aromatic compound quinoline, the name of which originated from the oily substance obtained after the alkaline distillation of quinine (Gerhardt, 1842).
Mechanism of Quinolone Action and Resistance - PMC
Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome. This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quinolone action against their enzyme targets.
Quinolone Antibiotics: Resistance and Therapy - PMC
By reviewing the association of quinolones with drug resistance and SOS response, we found that the current research on quinolones mainly focuses on two aspects including direct targeting action leading to lesions and indirect accumulation of poisons and cell death.
Most quinolones have excellent oral bioavailability, with serum drug concentrations equivalent to intravenous administration. Quinolones have few adverse effects, most notably nausea, headache,...
New Classification and Update on the Quinolone Antibiotics
2000年5月1日 · The quinolones can be differentiated within classes based on their pharmacokinetic properties. The new classification can help family physicians prescribe these drugs appropriately.