Thyroglobulin: Normal Range, High Levels & Thyroid Cancer
2021年1月20日 · Thyroglobulin is a protein used to make thyroid hormones. Doctors mainly check its levels to determine if thyroid cancer has returned after surgery and radiation. Thyroglobulin antibodies may point to autoimmune thyroid diseases such as Hashimoto’s and Graves’ disease.
Thyroglobulin - Wikipedia
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland ...
Thyroglobulin: MedlinePlus Medical Test
2022年9月8日 · Thyroglobulin is a protein that your thyroid makes. Your thyroid is a small, butterfly-shaped gland in your neck. It makes hormones that control many activities in your body, including your heart rate and how fast you burn calories from food. A thyroglobulin test is a type of tumor marker test.
Thyroglobulin, Tumor Marker, Serum - Mayo Clinic Laboratories ...
Thyroglobulin (Tg) is a thyroid-specific glycoprotein (approximately 660 kDa) that serves as the source for thyroxine (T4) and triiodothyronine (T3) production within the lumen of thyroid follicles. For T4 and T3 release, Tg is reabsorbed into thyrocytes and proteolytically degraded, liberating T4 and T3 for secretion.
Clinical use of thyroglobulin: not only thyroid cancer - PMC
Thyroglobulin (TG) is a 660 kDa dimeric glycoprotein produced exclusively by thyroid follicular cells and stored in the extracellular space of the thyroid, within the apical lumen. TG is crucial for the organification of iodine and is an organic matrix for the synthesis of iodothyrosines.
Thyroglobulin From Molecular and Cellular Biology to Clinical ...
Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization.
Thyroglobulin - an overview | ScienceDirect Topics
Thyroglobulin (Tg) is a large 660kDa dimeric glycoprotein composed of two identical polypeptide chains, and is unique in its content of iodinated amino acids. From: Comprehensive Handbook of Iodine, 2009
The structure of human thyroglobulin - PMC - PubMed Central …
Thyroglobulin is the protein precursor of thyroid hormones, which are essential for growth, development and control of metabolism in vertebrates1,2. Hormone synthesis from thyroglobulin (TG) occurs in the thyroid gland via the iodination and ...
Thyroglobulin | Pathology Tests Explained
2023年6月1日 · Thyroid follicle cells produce and store the thyroid hormones T4 or thyroxine and T3 or triiodothyronine as part of a protein called thyroglobulin, which occupies most of the centre of a follicle. When needed, the thyroglobulin is broken down to release thyroid hormones.
Thyroglobulin - an overview | ScienceDirect Topics
Thyroglobulin (Tg) is a glycoprotein hormone uniquely synthesized and secreted by both benign and malignant thyroid tissue. As such, serial Tg measurements have become a cornerstone in the longterm management of patients with differentiated thyroid cancer (DTC).