Fluorouracil - Wikipedia
WEBFluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer. [3]
Fluorouracil | C4H3FN2O2 | CID 3385 - PubChem
WEBDec 1, 2016 · Fluorouracil (5-FU) is a pyrimidine analogue used as an antineoplastic agent to treat multiple solid tumors including colon, rectal, breast, gastric, pancreatic, ovarian, bladder and liver cancer. Fluorouracil is associated with a low rate of transient serum aminotransferase elevations during therapy and has been implicated in rare cases of ...
5-Fluorouracil: mechanisms of action and clinical strategies
WEBMay 1, 2003 · The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite drug that is widely used for the treatment of cancer, particularly for colorectal cancer. 5-FU exerts its anticancer effects...
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
WEBAug 5, 2008 · 5-FU is a heterocyclic aromatic organic compound with a structure similar to that of the pyrimidine molecules of DNA and RNA; it is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen .
Fluorouracil: Uses, Interactions, Mechanism of Action - DrugBank …
WEBFor the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites.
5-Fluorouracil: A Narrative Review on the Role of Regulatory …
WEBApr 19, 2021 · 5-fluorouracil (5-FU) and its oral prodrugs including S1 and capecitabine (1) are among the main components of most chemotherapeutic regimens whose efficiencies have been established in the treatment of several neoplasms such as head and neck squamous cell carcinoma (SCC) (2), gastrointestinal SCC and adenocarcinoma (ADC) (3, 4), and SCC of the ...
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
WEBAug 5, 2008 · 5-FU is a heterocyclic aromatic organic compound with a structure similar to that of the pyrimidine molecules of DNA and RNA; it is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen .
5-Fluorouracil - an overview | ScienceDirect Topics
WEB5-Fluorouracil (5-FU) (Fig. 4.8) is a well-known primary chemotherapy drug from fluoropyrimidines (FPs). It is FDA-approved clinical cytostatic and cytotoxic drug, and it is considered as a typical chemotherapy drug that remains the backbone of treating several solid tumors [102,103].
Binding Pattern and Structural Interactome of the Anticancer Drug 5 ...
WEBMar 17, 2024 · The fluorine moiety of 5-FU forms hydrogen bonds with Y130 (3.1 Å) and C207 (3.8 Å). This detailed complex structure with 5-FU contributes valuable insights into understanding the catalytic specificity of VCZ, paving the way for further advancements in gene-directed enzyme prodrug therapy (GDEPT) .
Fluorouracil - StatPearls - NCBI Bookshelf
WEBFeb 16, 2024 · Fluorouracil, also known as 5-fluorouracil or 5-FU, belongs to the class of chemotherapy drugs used to treat various neoplasms. Systemic fluorouracil is approved by the US Food and Drug Administration (FDA) for the treatment of gastric adenocarcinoma, pancreatic adenocarcinoma, breast adenocarcinoma, and colorectal adenocarcinoma.
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