5-HT1A receptor - Wikipedia
网页The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney.
The 5-HT1A receptor: Signaling to behavior - PubMed
网页The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic heteroreceptor. This review examines the signaling of 5-HT1A receptors to regulate 5-HT activity and behavior.
The 5-HT1A Receptor: A Signaling Hub Linked to Emotional …
网页This review will compare and contrast existing data on expression and signaling activity of the brain 5-HT1A receptor. Our purpose is to critically assess the current understanding of those 5-HT1AR-mediated signaling cascades that are physiologically important and also to unravel the poorly understood processes that have yet to be delineated ...
聚焦5-HT1A受体，助力改善精神疾病患者认知功能 | 专家视角 - 知乎
网页非典型抗精神病药具有较强的突触后膜5-HT2A受体阻断作用，部分药物对5-HT1A受体具有部分激动作用（如阿立哌唑、齐拉西酮等），推测其可有限改善认知功能 [3]。. 近期一项纵向研究显示，与健康对照个体相比，首发精神病患者的左侧海马体积显著缩小。. 即使 ...
5-HT1A receptors in mood and anxiety: recent insights into …
网页Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT 1A) subtype, in both disorders.
5-HT1A受体及5-HT1A受体激动剂在精神神经疾病中的研究进展
网页2018年3月19日 · 5-HT 1A 受体是突触前膜树突上唯一的5-HT受体，可反馈性减弱神经冲动传导和减少5-HT的释放，进而调节5-HT神经元的活性。. 电生理研究表明5-HT 1A 激动剂能够抑制大鼠的5-HT神经元（位于中缝核）的放电，而5-HT 1A 拮抗剂则能够拮抗这种效应。. 体外实验也发现5-HT 1A ...
5-HT1A receptor as a key player in the brain 5-HT system
网页Among an impressive variety of identified serotonin receptors, 5-HT1A attracts particular attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the data on its involvement in the mechanisms of stress response, aggressive behavior, anxiety, and depression.
5-HT1A Receptor - an overview | ScienceDirect Topics
网页The 5-HT1A receptor is the most common and widely distributed subtype of the 5-HT receptor in the brain. It plays a crucial role in regulating serotonin activity and mediating its effects. Long-term antidepressant treatment enhances serotonergic neurotransmission, likely through its action on the 5-HT1A receptor.
The 5-HT1A receptor: Signaling to behavior - ScienceDirect
网页2019年6月1日 · This review examines the signaling of 5-HT1A receptors to regulate 5-HT activity and behavior. Initial findings in heterologous cell systems, neuronal cell lines, neurons, and in vivo show that the 5-HT1A receptor is a Gi/o-coupled receptor that signals to the canonical pathway of inhibition of adenylyl cyclase (AC).
Structure of serotonin receptors: molecular underpinning of …
网页2021年6月18日 · The resolved structures provide new insight into the mechanism underlying the high constitutive activity of 5-HT 1A receptors: the ligand-binding site in the structure of the 5-HT 1A receptor...