Amyloid beta - Wikipedia
网页Amyloid beta (Aβ) is a peptide derived from amyloid precursor protein (APP) that forms amyloid plaques in the brains of people with Alzheimer's disease. Learn about its normal function, disease associations, genetic and biochemical studies, and potential roles in prion-like misfolding and neurotoxicity.
Amyloid beta: structure, biology and structure-based …
网页2017年7月17日 · Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases.
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
网页2021年8月30日 · The Amyloid-β Pathway in Alzheimer’s Disease. Harald Hampel, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L. Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi...
β 淀粉样蛋白 (Aβ) - Abcam中文官网
网页β 淀粉样蛋白（Aβ 或 Abeta）是 β- 和 γ- 分泌酶切割淀粉样前体蛋白 (APP) 后形成的一系列蛋白肽，其被认为与阿尔茨海默症的发病过程相关。大脑中出现 β-淀粉样蛋白斑块，即细胞外的蛋白质沉积物，是阿尔茨海默症的一项主要标志。
Amyloid β-based therapy for Alzheimer’s disease: challenges
网页2023年6月30日 · Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s...
β淀粉样蛋白 - 维基百科，自由的百科全书
网页β淀粉样蛋白（Aβ或Abeta）是阿茲海默症患者大脑中发现的淀粉样蛋白斑块的主要成分，為来源于前類澱粉蛋白質的肽，長度介於36-43个氨基酸之間 [1] [2] 。
β-淀粉样蛋白 - 百度百科
网页在正常人中，Aβ是一种正常的、可溶的神经元代谢产物，调节几种关键的生理功能，对 突触可塑性 、 记忆 和 神经递质 释放发挥 神经调节 作用 [3]。 并且Aβ遵循Hormesis兴奋效应，在最佳浓度区间内，对人体有利，超过这个区间（过高/过低）对人体是有害的 [4]。 研究表明生理浓度（皮摩尔）对记忆是有益的，病理浓度（纳摩尔）对记忆是有害的 [9]。 从生理到病理的转变与Aβ水平的异常增加有关，这是由于Aβ产生和清除的不平衡。 而Aβ的产生和清 …
The Alzheimer's disease-associated amyloid beta-protein is an ... - PubMed
网页2010年3月3日 · Our findings suggest Abeta is a hitherto unrecognized AMP that may normally function in the innate immune system. This finding stands in stark contrast to current models of Abeta-mediated pathology and has important implications for ongoing and future AD treatment strategies.
Amyloid beta: structure, biology and structure-based therapeutic ...
网页Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases.
Amyloid Beta Peptide - StatPearls - NCBI Bookshelf
网页2023年8月28日 · Amyloid beta peptide is a 42-amino acid peptide and derives from the precursor protein, amyloid beta precursor protein (APP). The amyloid beta precursor protein is a transmembrane glycoprotein that spans the membrane once. The gene for amyloid beta precursor protein is on chromosome 21.