Ambroxol - ALZFORUM
网页2021年4月22日 · Ambroxol is a mucolytic compound and the main ingredient of over-the-counter cough medicines sold in many countries. Syrup, tablet, and other forms are used at doses of 30 to 120 mg per day to reduce or thin mucous secretions and ease sore throat pain. The most common side effects are gastrointestinal.
Ambroxol Hydrochloride Improves Motor Functions and Extends
网页Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis. Front Pharmacol. 2019;10:883. Epub 2019 Aug 7 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Ambroxol for the Treatment of Patients With Parkinson Disease …
网页Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial. JAMA Neurol. 2020 Apr 1;77(4):427-434. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must …
Therapeutics Search - ALZFORUM
网页Ambroxol: Ambrosan, Mucosolvan: Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) alpha-synuclein, Other: Small Molecule: Apabetalone: RVX208, RVX000222: MCI-VaD (Phase 3) Resverlogix Corporation: Other: Small Molecule: AQW051: Alpha-7 nicotinic acetylcholine receptor agonist
Therapeutics Search - ALZFORUM
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Large Phase 2 Trial Starting Up in Genetic Parkinson’s Population
网页2014年6月13日 · A Phase 2 trial has been approved by the Food and Drug Administration and will begin enrolling this month, with completion scheduled for 2022, Sardi said. The study will enroll about 230 people who have Parkinson’s and a GBA mutation. Although this initial trial only includes mutation carriers, the researchers believe the strategy may work …
Therapeutics Search - ALZFORUM
网页Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company. Amyloid-Related, Inflammation. Immunotherapy (passive) Docosahexaenoic acid (DHA) Omega-3 fatty acid. Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc.
Parkinson’s Treatments Go After Genetic Targets | ALZFORUM
网页Other researchers are developing the cough medicine Ambroxol as a GBA therapy. In Turin, Anthony Schapira of University College London explained that Ambroxol seems to act as a chaperone, binding mutant GBA in the endoplasmic reticulum and escorting it through the Golgi apparatus to the lysosome for degradation. In cellular and animal models of ...
TDP-43 (Q331K) - ALZFORUM
网页2018年3月6日 · Consistent with TDP-43 autoregulation, a decrease in endogenous murine levels was observed in transgenic mice. Transgene expression was highest in the brain and spinal cord with very low levels observed in other tissues. At birth, the TDP-43 Q331K mice were indistinguishable from non-Tg littermates. Tremor was observed as early as three to …
Memantine - ALZFORUM
网页2023年10月9日 · Memantine's side effects include fatigue, increases in blood pressure, dizziness, headache, constipation, confusion, and sleepiness, among others. Memantine is the only FDA-approved drug for the treatment of Alzheimer's disease that is not an acetyl cholinesterase inhibitor. The drug is a noncompetitive, low- to medium-affinity antagonist …