A Systematic Review of Single-Dose Aminoglycoside Therapy for …
网页2018年12月21日 · Single-dose aminoglycoside therapy appears to be an effective treatment option for lower UTI in nonseptic patients, with minimal toxicity. Additional studies would be beneficial to confirm efficacy for pyelonephritis. When resistance to first-line UTI agents is endemic, aminoglycosides may serve as β-lactam- and fluoroquinolone-sparing options.
A Systematic Review of Single-Dose Aminoglycoside Therapy for ... - PubMed
网页2018年12月21日 · Single-dose aminoglycoside therapy appears to be an effective treatment option for lower UTI in nonseptic patients, with minimal toxicity. Additional studies would be beneficial to confirm efficacy for pyelonephritis. When resistance to first-line UTI agents is endemic, aminoglycosides may serve as β-lactam- and fluoroquinolone-sparing options.
Aminoglycosides - UpToDate
网页2022年12月12日 · This topic will review basic issues related to the clinical use of parenteral aminoglycosides, including mechanism of action, spectrum of activity, and adverse effects. Dosing and monitoring of aminoglycosides and administration in certain patient populations are discussed elsewhere.
网页Tradition dosing of aminoglycosides includes lower doses with more frequent administration of aminoglycosides using pharmacokinetic parameters to determine dose and frequency to achieve target peak and trough values. Indication: • Treatment of gram-negative infections and NOT a candidate for high-dose extended interval dosing therapy (see
Efficacy and safety of aminoglycoside monotherapy: systematic …
网页2007年6月11日 · Aminoglycoside treatment for urinary tract infection. This review demonstrates that aminoglycoside antibiotics are equally effective as comparator antibiotics: β-lactams or quinolones in achieving a clinical improvement in patients with urinary tract infection (UTI).
网页Aminoglycosides (AG): - Due to increasing resistance among various antibiotic classes used to treat UTIs (e.g. fluoroquinolones, SMX/TMP), alternative agents with activity against multidrug resistant (MDR) bacteria are required - AGs have retained excellent activity against MDR urinary pathogens (e.g. ESBL Escherichia coli)
2781. The Use of Aminoglycosides for Treatment of Urinary Tract ...
网页Aminoglycosides are known to be effective therapy for UTIs, however their use is not common due to a fear of nephrotoxicity. Overuse of broad-spectrum antimicrobial agents, particularly carbapenems can lead to colonization with carbapenem-resistant pathogens resulting in more difficult-to-treat infections.
Prospective evaluation of single‐dose aminoglycosides for …
网页2024年3月7日 · Single-dose aminoglycosides may provide a convenient alternative for those with or at risk for resistant pathogens causing complicated urinary infections, especially when oral options are unavailable due to resistance, allergy, intolerance, or interactions with other medications.
Efficacy and safety of aminoglycoside monotherapy: systematic review ...
网页Aminoglycosides. Anti-Bacterial Agents. The present data support the use of aminoglycosides for urinary tract infections. The paucity of trials including patients with sepsis or reporting on mortality precludes firm recommendations for patients with infections other than of the urinary tract.
Once-Daily Plazomicin for Complicated Urinary Tract Infections
网页2019年2月20日 · Aminoglycosides are an alternative treatment for complicated UTIs that are caused by multidrug-resistant organisms, such as extended-spectrum β-lactamase–producing Enterobacteriaceae or ...
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