Cycloheximide - Wikipedia
网页Cycloheximide is a naturally occurring fungicide produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation.
Cycloheximide | Cell Signaling Technology
网页Cycloheximide is a protein synthesis inhibitor in eukaryotes. Although its precise mechanism of action has yet to be fully elucidated, it has been shown to inhibit translation elongation through binding to the E-site of the 60S ribosomal unit and interfering with deacetylated tRNA (1-3).
Inhibition of eukaryotic translation elongation by cycloheximide …
网页2010年1月31日 · Among the known inhibitors of eukaryotic translation is cycloheximide (CHX, 1), the most common laboratory reagent used to inhibit protein synthesis (Fig. 1). CHX has been shown to block the...
Cycloheximide (CHX) Chase Assay to Examine Protein Half-life
网页2023年6月5日 · Cycloheximide (CHX) is a small molecule derived from Streptomyces griseus that acts as fungicide. As a ribosome inhibitor, CHX can restrict the translation elongation of eukaryotic protein synthesis.
Cycloheximide | C15H23NO4 | CID 6197 - PubChem
网页Cycloheximide | C15H23NO4 | CID 6197 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Cycloheximide - an overview | ScienceDirect Topics
网页Cycloheximide (52, also known as naramycin A or actidione) was first isolated in 1946 from Streptomyces griseus. 15 It remains as one of the most famous glutarimide natural products and displays a wide variety of biological activities, including broad antibiotic, antifungal, antitumor, and amebicidal activities, as well as serving as an ...
Cycloheximide - an overview | ScienceDirect Topics
网页Cycloheximide (CHX; mol. wt. 281.35) is a beige colored, crystal powdered, water-soluble, semisynthetic compound, isolated as a by-product from beers of streptomycin-producing strain of a Streptomyces species. CHX, a popular inhibitor of protein synthesis, also stimulates glycogenolysis, gluconeogenesis, and ureogenesis; therefore, it is ...
Cycloheximide - an overview | ScienceDirect Topics
网页Cycloheximide is a broad based protein synthesis inhibitor that blocks the levels of cyclin B, a component of MPF. However, its potential effects on embryo and fetal development were unknown. Therefore, this laboratory investigated the effects of …
Deciphering the Relationship Between Cycloheximides Structures …
网页2021年4月7日 · In this study, cycloheximide (CH) and acetoxycycloheximide (ACH) were isolated from the fermentation broth of Streptomyces sp. JCK-6092. The antifungal and phytotoxic activities of the two compounds (CH and ACH) and a cycloheximide derivative, hydroxycycloheximide (HCH), were compared.
Cycloheximide promotes paraptosis induced by inhibition of …
网页2017年5月18日 · Although cycloheximide has been claimed to suppress paraptosis, instead we find that it only temporarily delayed vacuole formation, but actually enhanced paraptotic cell death in the long term.