Cytokine Release Syndrome: Symptoms, What It Is & Treatment
2022年4月7日 · What is cytokine release syndrome? Cytokine release syndrome (CRS) — sometimes called cytokine storm or cytokine-associated toxicity — is a condition that develops when your immune system responds too aggressively to infection. It can also happen after certain types of immunotherapy, such as CAR T-Cell Therapy.
Cytokine release syndrome (CRS) - UpToDate
2024年4月2日 · Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction. CRS is most often associated with chimeric antigen receptor (CAR)-T cell therapy, but it also occurs in association with bispecific T cell engager therapy, other monoclonal antibody-based therapy, haploidentical ...
Cytokine release syndrome - Wikipedia
In immunology, cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. [3] It refers to cytokine storm syndromes (CSS) [ 4 ] and occurs when large numbers of white blood cells are activated and release inflammatory cytokines ...
什么是细胞因子释放综合征？ - 知乎 - 知乎专栏
细胞因子释放综合征（cytokine release syndrome，CRS）也被称为细胞因子风（cytokine storm），是一种因免疫细胞被激活 并释放大量细胞因子而引发的严重全身炎症反应综合征，临床表现以发热和多器官功能障碍为特…
Cytokine Release Syndrome: Symptoms, Causes, Treatments
2024年5月2日 · Cytokine release syndrome occurs when many cytokines flood the body at once, often after an infusion or injection of antibodies. This sends the body’s immune system into overdrive, prompting an inflammatory response. Medications that treat cancer by affecting the body’s T-cells can also lead to cytokine release syndrome.
Cytokine Release Syndrome: Symptoms, Causes, Treatments - Healthline
2022年10月5日 · Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection. It happens when an immune system communication protein called cytokine is overproduced...
Management of Cytokine Release Syndrome (CRS) and HLH
2022年2月7日 · Cytokine release syndrome (CRS) is caused by a rapid and mild to massive release of cytokines from immune cells involved in immune reactions, particularly after immunotherapy. The frequency and severity of CRS after CAR-T cell therapy varies between products (any grade: 37–93%, G3/4: 1–23%) (Neelapu et al. 2017; Schuster et al. 2019 ...
Cytokine release syndrome - PMC
Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by a variety of factors such as infections and certain drugs.
细胞因子释放综合征 - UpToDate
细胞因子释放综合征 (cytokine release syndrome, CRS)是一种急性全身性炎症综合征，表现为发热和多器官功能障碍，最常与嵌合抗原受体 (chimeric antigen receptor, CAR)-T细胞治疗相关，但也可能与双特异性T细胞衔接器治疗、其他单克隆抗体治疗、半相合异基因移植等相关。 免疫效应细胞相关神经毒性综合征 (immune effector cell-associated neurotoxicity syndrome, ICANS)是一种神经精神综合征，可发生在接受免疫治疗的一些患者中，可能伴有CRS。 本专题将讨论CRS …
Cytokine Release - an overview | ScienceDirect Topics
Evidence suggests poorer clinical outcomes in respiratory viral infections in humans and animal models associated with elevated levels of cytokine and chemokine production [63–65].