Assessment of stereoselectivity in pharmacology, toxicology, and …
Jan 1, 2020 · For example, the β-receptor blocker carvedilol interacts with digoxin, amiodarone, CsA, nicardipine, nifedipine, fluoxetine, and other drugs, some of which are resulting from inhibiting P-gp-mediated transport, and thus regulating the blood levels of coadministered drugs, and others are resulting from metabolic interactions [41].
Direct Electrochemical Aptamer-Based Detection of Digoxin
Feb 24, 2020 · The developed electrochemical aptamer-based digoxin sensor provides a distinct and amplified peak current response in the therapeutic range of 0.5 ng/mL to 2.0 ng/mL in a phosphate buffer saline solution. We suggest this approach as a conceptual pathway to point-of-care digoxin sensor design.
Determination of the enantioselectivity of six chiral aryloxy ...
Apr 1, 2012 · As digoxin is a typical substrate of P-gp, so carvedilol is likely to have the ability to inhibit P-gp. This result has been proved on MDR1-transfected Madin-Darby canine kidney (MDR1-MDCK) cells; these MDR1-mediated reversing effects of carvedilol on vinblastine, paclitaxel, doxorubicin and daunorubicin were similar to those of verapamil 29 .
Digoxin: Pharmacology and toxicology—A review - ScienceDirect
Oct 1, 2020 · Digoxin is one of the oldest used medicaments in cardiology. It works by increasing myocardial contractility, increasing stroke volume and blood pressure, reducing heart rate, and somewhat extending the timeframe of a contraction. It can result in an improvement of myocardial function and hemodynamics, alongside augmented perfusion of tissues.
Digoxin: Pharmacology and toxicology-A review - PubMed
Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow therapeutic window of the medication.
A Comprehensive Review on Unveiling the Journey of Digoxin: …
Mar 23, 2024 · Digoxin exerts its primary mechanism of action by inhibiting the sodium-potassium adenosine triphosphatase (Na+/K+ ATPase) enzyme, particularly within the myocardium. This inhibition results in an accumulation of intracellular sodium, which diminishes the sodium-calcium exchanger's activity.
Digoxin - StatPearls - NCBI Bookshelf
Jan 19, 2023 · Digoxin is a medication used to manage and treat heart failure, certain arrhythmias, and abortion. It is in the cardiac glycoside class of drugs. This article outlines the indications, actions, and contraindications for digoxin as a valuable agent in managing heart failure and certain arrhythmias.
Development of a new ultra-high-performance liquid ... - PubMed
The aim of this study was to develop and validate an original UPLC-MS/MS method for the determination of digoxin and digitoxin in plasma. The method shows adequate sensitivity and selectivity with acceptable matrix effects and very good linearity, accuracy, precision, and …
Selectivity analyses of γ-benzylidene digoxin derivatives to …
Nov 8, 2017 · Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzylidene digoxin derivatives) with substitutions in ...
Treatment with digoxin: Initial dosing, monitoring, and dose ...
Aug 21, 2023 · The initiation of digoxin therapy has been divided into rapid and slow digitalization followed by the maintenance digoxin dose, and the proposed regimens vary considerably. The following principles should be viewed as a general guide to the use of digoxin for its inotropic or electrophysiologic effects, which must be modified according to ...