Dihydrofolate reductase - Wikipedia
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in one-carbon transfer chemistry. In humans, the DHFR enzyme is …
Dihydrofolate Reductase - an overview | ScienceDirect Topics
Dihydrofolate reductase is an enzyme that converts dihydrofolate to tetrahydrofolate and is involved in purines and thymidylate synthesis. It is encoded by the human DHFR gene. Antifolate drugs, methotrexate (MTX) and trimetrexate, can tightly bind to DHFR and inhibit DNA synthesis and cell proliferation.
Dihydrofolate Reductase - an overview | ScienceDirect Topics
Dihydrofolate reductase (DHFR) inhibitors prevent the formation of tetrahydrofolate from dihydrofolate in the biosynthesis pathway for folic acid. The DHFR enzyme is essential for bacterial survival.
Dihydrofolate Reductase - an overview | ScienceDirect Topics
Dihydrofolate reductase (DHFR) is a ubiquitous enzyme, which plays an essential role in the biosynthesis of tetrahydrofolate cofactors Freisheim and Matthews (1984), Blakley (1984), Burchall (1983). Several forms of these cofactors are required in the synthesis of purines, amino acids such as glycine and methionine, and thymidine .
Optimized peptide based inhibitors targeting the dihydrofolate ...
2018年2月16日 · We report the first peptide based hDHFR inhibitors designed on the basis of structural analysis of dihydrofolate reductase (DHFR). A set of peptides were rationally designed and synthesized...
(PDF) Dihydrofolate reductase: Structural aspects of mechanisms …
2001年1月10日 · The mechanism of catalytic reduction of folic and dihydrofolic acids to tetrahydrofolate, which proceeds under the action of dihydrofolate reductase and the coenzyme NADPH, is considered.
Dihydrofolate_Reductase - University of Virginia
The reaction pathway catalyzed by DHFR can be split into five distinct kinetic intermediates: a holoenzyme form bound to NADPH, a Michaelis complex with NADPH and DHF, a transition state complex, a THF binary complex, and a THF-NADPH complex (7).
Dihydrofolate Reductase Gene Variations in Susceptibility to …
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation.
DHFR Gene - GeneCards | DYR Protein | DYR Antibody
2024年12月9日 · Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes ...
BMRB Featured System: Dihydrofolate Reductase
Dihydrofolate Reductase (DHFR; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase) is a very important enzyme because it produces cofactors that are necessary for DNA synthesis. Specifically, DHFR catalyzes the reduction of folate and 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate (THF).
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