Epigenetic Modification - an overview | ScienceDirect Topics
Epigenetic modification refers to a reversible and heritable change in gene expression in the absence of a change in the DNA sequence in the nucleus; this modification includes chromatin remodeling, DNA methylation, and histone modification.
Epigenetic Modifications: Basic Mechanisms and Role in …
2011年5月5日 · Here, we review the major mechanisms in epigenetic regulation; highlight the role of stable, long-term epigenetic modifications that involve DNA methylation; and discuss those modifications that are more flexible (short-term) and involve histone modifications, such as methylation and acetylation.
What is epigenetics? - MedlinePlus
2021年6月11日 · Epigenetic changes are modifications to DNA that regulate whether genes are turned on or off. These modifications are attached to DNA and do not change the sequence of DNA building blocks. Within the complete set of DNA in a cell (genome), all of the modifications that regulate the activity (expression) of the genes is known as the epigenome.
Epigenetic modifications and human disease - Nature
2010年10月13日 · The most widely studied epigenetic modification in humans is cytosine methylation. DNA methylation occurs almost exclusively in the context of CpG dinucleotides.
Epigenome editing technologies for discovery and medicine
2024年7月29日 · Editing epigenetic modifications and/or chromatin structure enables precise, tunable control of gene expression by repurposing natural mechanisms of gene control, circumventing DNA damage- and...
The molecular hallmarks of epigenetic control - Nature
2016年6月27日 · Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and associated mechanisms that alter chromatin in response to physiological or pathological signals have transformed...
Epigenetic Regulation and Measurement of Epigenetic Changes
The purpose of this paper is to describe three of the best characterized forms of epigenetic regulation: histone modification, DNA methylation, and noncoding ribonucleic acid (RNA) expression. In addition, we describe the most common methods used to measure these epigenetic changes.
Epigenetic Mechanisms: DNA Methylation and Histone Protein Modification …
2022年10月18日 · Together, these studies indicate that in response to environmental stimuli, several epigenetic modifications, including lasting changes in histone acetylation, histone methylation, and DNA methylation, cooperate and create patterns of “epigenetic coding” designed to bring about specific changes in gene expression and ensure proper neural ...
Genetics, Epigenetic Mechanism - StatPearls - NCBI Bookshelf
2023年8月14日 · Three different epigenetic mechanisms have been identified: DNA methylation, histone modification, and non-coding RNA (ncRNA)-associated gene silencing. Catalyzed by DNA methyltransferase enzymes, DNA methylation involves the addition of a methyl group directly to a cytosine nucleotide within a cytosine-guanine sequence (CpG), which are often ...
Epigenetic Modification - an overview | ScienceDirect Topics
Epigenetic modifications include a variety of molecular mechanisms such as DNA methylation, histone modification, and non-coding RNAs that change the expression of a gene without altering its DNA sequence. Such modifications can persist, via mitosis in a developing organism, or, even via meiosis from one generation to the next.