GABAA receptor - Wikipedia
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.
GABAA receptors: structure, function, pharmacology, and related ...
2021年8月21日 · γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications. Main body.
GABAA receptors: structure, function, pharmacology, and …
2021年8月21日 · Background: γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.
Structure, Function, and Modulation of GABAA Receptors*
The GABAA receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA.
Structure of a human synaptic GABAA receptor | Nature
2018年6月27日 · Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA receptor).
GABAA receptors - PMC - National Center for Biotechnology …
GABA A receptors are GABA-gated anion channels responsible (together with ligand-gated glycine receptors) for most fast inhibitory synaptic transmission in the vertebrate central nervous system. GABA A receptors are permeable to HCO 3 − and Cl − ions; the permeability ratio of HCO 3 − ∕ Cl − is approximately 0.2 to 0.4 (reviewed in ...
Understanding GABAA receptor pharmacology - Nature
2023年10月5日 · Type A γ-aminobutyric acid receptors (GABA A Rs) are the main fast inhibitory neurotransmitter receptors in the brain and targets for several drugs used in the treatment of depression,...
GABAA receptor signalling mechanisms revealed by structural ... - Nature
2019年1月2日 · Type-A γ-aminobutyric (GABA A) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are...
Structure, function, and modulation of GABA(A) receptors
2012年11月23日 · The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA.
Structure, Function, and Modulation of GABAA Receptors
2012年11月11日 · The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA.