Long-Range GABAergic Inputs Regulate Neural Stem Cell …
Nov 2, 2017 · The quiescence of adult neural stem cells (NSCs) is regulated by local parvalbumin (PV) interneurons within the dentate gyrus (DG). Little is known about how local PV interneurons communicate with distal brain regions to regulate NSCs and hippocampal neurogenesis. Here, we identify GABAergic projection neurons from the medial septum (MS) as the ...
Nat Rev Neurosci：海马齿状回环路与情景记忆的编码、提取和分辨
Apr 14, 2020 · 在DG区有几种类型GABA能抑制性中间神经元，研究最深入的是表达小清蛋白的中间神经元（PV+），包括轴突-轴突细胞（AAC）和篮状细胞。 另一主要细胞类型是树突靶向抑制性细胞，最突出的是表达生长抑素的中间神经元（SOM+）。 表1：DG区各类细胞的突触连接来源和体内活动模式. DG区的突触输入. 内嗅皮层（EC）为海马提供了来自于皮层的主要输入。 MEC包含了几种空间调控细胞类型，比如边界、头部朝向、目标导向和网格细胞。 网格细胞 …
Dynamic interplay between GABAergic networks and developing …
Aug 1, 2021 · The interplay between adult neurogenesis and GABA interneurons emerges as a robust candidate to confer processing flexibility to the DG network. Why PV-INs seem more efficient in driving developmental and plasticity programs than other GABAergic interneurons, and how new neurons integrate a space of complementary signals to decide how far to ...
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GABA Receptor - StatPearls - NCBI Bookshelf
Feb 13, 2023 · GABA receptors are receptors that respond when GABA is released into the post-synaptic nerve terminal. They are considered the chief inhibitory receptors for the central nervous system. GABA receptors are subdivided into GABAa and GABAb. [2] GABAa is classified as a ligand-gated ion channel/inotropic receptor.
The effect of age and sex on the expression of GABA signaling ...
Nov 2, 2021 · However, the observed sex-specific negative correlation of GABA A α1, β1, β3, and γ2 subunit expression with age, particularly in the DG and CA1 subregion, and the positive correlation of the...
Regulation of adult neurogenesis by GABAergic transmission: …
Jun 20, 2014 · In the adult mammalian brain, neurogenesis occurs in the olfactory bulb (OB) and in the dentate gyrus (DG) of the hippocampus. Several studies have shown that multiple stages of neurogenesis are regulated by GABAergic transmission with precise spatio-temporal selectivity, and involving mechanisms co ….
Hippocampal GABAergic interneurons and memory - Cell Press
Jul 18, 2023 · As the hippocampus plays a pivotal role in memory, our review focuses on three aspects: (1) delineation of hippocampal interneuron types and their connectivity, (2) interneuron plasticity, and (3) activity patterns of interneurons during memory-related rhythms, including the role of long-range interneurons and disinhibition.
GABA–glutamate supramammillary neurons control theta and …
Sep 24, 2020 · Several studies suggest that neurons from the lateral region of the SuM (SuML) innervating the dorsal dentate gyrus (DG) display a dual GABAergic and glutamatergic transmission and are specifically activated during paradoxical (REM) sleep (PS).
A high-resolution transcriptomic and spatial atlas of cell types in …
Dec 13, 2023 · We identified two subclasses of immature neurons, 38 DG–PIR Ex IMN grouped with glutamatergic granule cells in DG to form the DG–IMN Glut class, and 45 OB–STR–CTX Inh IMN grouped with ...