Gene targeting - Wikipedia
Gene targeting is a biotechnological tool used to change the DNA sequence of an organism (hence it is a form of Genome Editing). It is based on the natural DNA-repair mechanism of Homology Directed Repair (HDR), including Homologous Recombination.
基因靶向 - 百度百科
基因靶向（英语：gene targeting，又称为基因打靶）是一种利用同源重组方法改变生物体某一内源基因的遗传学技术。 这一技术可以用于删除某一基因、去除外显子或导入点突变，从而可以对此基因的功能进行研究。
十年诺奖回顾｜基因打靶技术——记2007年生理学及医学奖 - 知乎
任何 细胞外在生存条件改变、内在氧化、机械损伤，甚至进行 细胞复制 的时候，都有可能会出现 DNA的单链或者双链断裂！ 不过，细胞也不是吃素的（不要跟我说是吃培基的（＃－.－）），通过进化，逐渐形成了一套 DNA损伤修复系统。 主要有两种方法： ↑↑↑同源重组 其实就是我们高中课本学到的， 非姐妹染色单体 之间的同源区段进行重新组合的过程。 Their discoveries led to the creation of an immensely powerful technology referred to as gene targeting in mice. 他们的发 …
基因靶向 - 维基百科，自由的百科全书
基因靶向 [1] [2] （英語： gene targeting ）又称基因打靶，是一种利用同源重组方法改变生物体某一内源 基因的遗传学技术。 这一技术可以用于删除某一基因、去除 外显子 或导入 点突变 ，从而可以对此基因的功能进行研究。
Gene targeting - Latest research and news | Nature
2024年12月19日 · Gene targeting is the process of altering a specific sequence or gene at its location in a genome. Potential modifications include deletion, insertion or...
Gene Targeting - an overview | ScienceDirect Topics
Gene targeting is commonly referred to as the process in which a cell’s recombination machinery integrates a piece of foreign DNA into its own genome at a target locus homologous to the foreign donor. The process of gene targeting has several common features in different organisms.
Gene Targeting - an overview | ScienceDirect Topics
Gene targeting is a method that uses homologous recombination and embryonic stem cell technology to introduce mutations into a specific gene of interest. This technique relies on the capability to access known sequences of the mouse genome and the development of mouse embryonic stem cells.
Gene Targeting in Mice: a Review - PMC - PubMed Central (PMC)
The introduction of site-specific modifications into the genome of ESCs by homologous recombination, a process called gene targeting, is achieved through the introduction of a targeting vector into ESCs by electroporation (Fig. 1 and 2).
Gene targeting in mice: functional analysis of the mammalian
2005年6月1日 · Gene targeting in mouse embryonic stem cells has become the 'gold standard' for determining gene function in mammals. Since its inception, this technology has revolutionized the study of...
Gene Targeting - SpringerLink
2017年7月26日 · Gene targeting is the process of making specific changes to the DNA of a cell or an organism that can be permanent or conditional. The ability to engineer biological systems holds immense potential for applications across basic science, medicine, and biotechnology.
- 某些结果已被删除