Primordial germ cell migration - Wikipedia
Primordial germ cell (PGC) migration is the process of distribution of primordial germ cells throughout the embryo during embryogenesis. Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes. [2] .
Germ Cell Migration - Developmental Biology - NCBI Bookshelf
Germ cell migration in Drosophila. During Drosophila embryogenesis, the primordial germ cells move from the posterior pole to the gonads (Figure 19.12). The first step in this migration is a passive one, wherein the 30–40 pole cells are displaced into the posterior midgut by the movements of gastrulation.
Mechanisms guiding primordial germ cell migration: strategies …
Primordial germ cell (PGC) migration provides a useful system for studying a group of individually migrating cells in vivo. PGC migration in all species follows similar steps:...
Mechanisms guiding primordial germ cell migration: strategies …
Primordial germ cell (PGC) migration provides a useful system for studying a group of individually migrating cells in vivo. PGC migration in all species follows similar steps: initiation of polarity and directed migration, regulated migration by attractive and repulsive cues, and termination of migration at the site of gonad formation.
Germ cell migration—Evolutionary issues and current understanding ...
2020年4月1日 · In this review, we propose that the process of germ cell migration confers an evolutionary advantage to multicellular organisms by enhancing their evolvability. According to this hypothesis, the ability of PGCs to migrate is compatible with the …
Finding their way: themes in germ cell migration - PMC
The study of germ cell migration has yielded valuable insights into how cells navigate several tissues in a dynamic environment to reach their target. Despite mechanistic differences in migrational paths and guidance cues, the themes required for germ cell migration remain remarkably conserved across model organism species.
Mammalian germ cell migration during development, growth, and ...
2019年6月9日 · Main findings: Germ cells migrate with various patterns, with each migration step regulated by distinct mechanisms. During development, PGCs actively and passively migrate from the extraembryonic region toward genital ridges through the hindgut epithelium.
Finding their way: themes in germ cell migration - ScienceDirect
2016年10月1日 · The study of germ cell migration has yielded valuable insights into how cells navigate several tissues in a dynamic environment to reach their target. Despite mechanistic differences in migrational paths and guidance cues, the themes required for germ cell migration remain remarkably conserved across model organism species.
The journey of a generation: advances and promises in the study …
2024年4月12日 · Here, we discuss recent findings on the migratory path, the somatic cells that shepherd PGCs, the guidance cues somatic cells provide, and the PGC response to these cues to reach the gonad and establish the germline pool for future generations. We end by discussing the fate of wayward PGCs that fail to reach the gonad in diverse species.
The Mechanism for Primordial Germ-Cell Migration Is Conserved …
2011年9月12日 · Primordial germ cells (PGCs) are segregated and specified from somatic cells during early development. These cells arise elsewhere and have to migrate across the embryo to reach developing gonadal precursors. Several molecules associated with PGC migration (i.e. dead-end, nanos 1, and cxcr 4) are highly conserved across phylum boundaries.
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