Histone acetyltransferase - Wikipedia
网页Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off.
ACL and HAT1 form a nuclear module to acetylate histone H4K5 …
网页2023年6月5日 · Histone acetylation is deposited by histone acetyltransferases (HATs) that transfer an acetyl group from acetyl coenzyme A (acetyl-CoA) to the lysine ε-amino groups on the...
Histone acetyltransferase complexes: one size doesn't fit all
网页A histone acetyltransferase (HAT) can be defined as an enzyme that acetylates core histones, which results in important regulatory effects on chromatin structure and assembly, and gene...
Histone Acetyltransferase - an overview | ScienceDirect Topics
网页Histone acetyltransferases (HATs) are acetyltransferases that acetylate lysines within lysine-rich amino-terminal tails of histone proteins, resulting in charge neutralization and a more relaxed, open, and transcriptionally active chromatin structure. They transfer an acetyl group from acetyl CoA to form ɛ-N-acetyllysine.
Histone acetyltransferases - PubMed
网页This review discusses our current understanding of histone acetyltransferases (HATs) or acetyltransferases (ATs): their discovery, substrate specificity, catalytic mechanism, regulation, and functional links to transcription, as well …
Writers and Readers of Histone Acetylation: Structure, …
网页Histone acetyltransferases (HATs), sometimes referred to as lysine acetyltransferases or KATs, form a superfamily of enzymes that acetylate the side-chain amino group of lysine residues on histones, and in some cases also other proteins.
Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase ...
网页2023年5月1日 · Histone acetyltransferases (HATs) are implicated as both oncogene and nononcogene dependencies in diverse human cancers. Acetyl-CoA-competitive HAT inhibitors have emerged as potential cancer...
Histone Acetyltransferase Assays in Drug and Chemical Probe …
网页2017年7月26日 · Histone acetyltransferases (HATs) are a class of epigenetic enzymes involved in critical cellular processes like nucleosome assembly, DNA damage repair, and transcriptional regulation. HATs are implicated in many …
Histone Acetyltransferase - an overview | ScienceDirect Topics
网页Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine residuals on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine. This modification neutralizes the positive charge of lysine and may thus disrupt the interaction between DNA and histone tails.
Histone acetyltransferases: challenges in targeting bi-substrate ...
网页2016年5月26日 · Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes.