Microencapsulation for the Therapeutic Delivery of Drugs, Live ...
The main biopharmaceutical goals of microencapsulation: microencapsulation can be used to achieve material structuration, therapeutic product protection, and targeted delivery and/or controlled release of the encapsulated biotherapeutics.
Microenvironment-Controlled Encapsulation (MiCE) Process: …
2007年10月4日 · A new MiCE microencapsulation process based on the natural jet segmentation employed in flow cytometry has been explored. The microencapsulation proceeds via hydrodynamic focusing of the component drug and PLGA solutions into a narrowed jet, which is then segmented due to Rayleigh-type instabilities within a quartz microchannel.
Microencapsulation-based cell therapies - PMC
The most common microencapsulation approaches to hepatic repair for fibrosis include the utilisation of mesenchymal stem cells (MSCs) which have been shown to secrete anti-inflammatory cytokines, and various growth factors that lead to a reduction in the progression of fibrotic disease whilst preventing immune system recognition when ...
Microenvironment-controlled encapsulation (MiCE) process: …
The MiCE microencapsulation process allows effective monitoring and control of the instrumental parameters affecting microcapsule production. However, the microcapsule collection method in this process needs to be further optimized to obtain microcapsules with desired morphologies, precise membrane …
Microencapsulated human mesenchymal stem cells decrease …
2015年3月1日 · In the present study, we investigated whether immunoprotection by microencapsulation prevents MSCs from participating to scar formation and allows MSCs to mediate an anti-fibrotic effect by releasing soluble molecules in vitro and in vivo. We found that MSC-conditioned medium (MSC-CM) reduced alpha smooth muscle actin …
Microencapsulation-based cell therapies | Cellular and Molecular …
2022年6月8日 · For the treatment of diseases such as type I diabetes that requires insulin release regulated by the patient's metabolic needs, microencapsulation may be the most effective therapeutic strategy. However, new materials need to be developed, so that transplanted encapsulated cells are able to survive for longer periods in the host.
Sodium alginate microencapsulation improves the short-term …
2021年6月17日 · In this study, we utilised the established sodium alginate microencapsulation method to develop CBD capsules and assess the abundance of CBD in plasma and brain samples of wild-type mice. Furthermore, we administered CBD capsules alongside DCA capsules to examine the blood-to-brain kinetics of CBD in conjunction with a permeation enhancer.
Aqueous-based microencapsulation enhances virus-specific humoral …
1996年9月1日 · In this paper we determined the capacity of aqueousbased microcapsules to enhance rotavirus-specific immune responses after i.m. inoculation with small quantities of antigen. These findings shed light on possible mechanisms of enhancement and may be relevant to vaccine strategies that include parenteral immunization.
Cell microencapsulation - ScienceDirect
2023年1月1日 · Microencapsulation is a procedure in which cells are embedded in microsized hydrogels and transferred to host tissue. In this technique, cells were placed within a permeable membrane to prolong cell retention in host tissue and prevent rejection by host tissue.
Microencapsulation as a Protective Strategy for Sialylated ...
2024年2月7日 · Sialylated immunoglobulin G (IgG) is a vital glycoprotein in breast milk with the ability to promote the growth of Bifidobacterium in gut microbiota and relieve inflammatory bowel disease (IBD) symptoms in vitro.