Characterizing EBV-associated lymphoproliferative diseases and the …
2021年1月14日 · EBV-associated T/NK cell diseases harbor large expansions of myeloid-derived suppressor cells that may suppress the antiviral T-cell response. EBV-infected T cells and NK cells persist in patients in large numbers following treatment.
EBV and post-transplant lymphoproliferative disorder: a complex ...
2024年12月6日 · We highlight the fact that patients with quintessential EBV-associated PTLD—including those with monomorphic DLBCL—can be cured with low-intensity therapeutic approaches such as reduction in immune suppression, surgical resection, rituximab monotherapy, or rituximab plus low-dose chemotherapy.
EBV-Driven Lymphoproliferative Disorders and Lymphomas of the ...
2021年9月8日 · Epstein–Barr virus (EBV)-associated lymphoproliferative disorders have been garnering attention in recent years. EBV infects people primarily in their first years of life. The viral genome is maintained in a latent phase within the host cells, usually B-lymphocytes.
Epstein-Barr-Virus-Related Lymphoproliferative Disorder in a …
Primary myelofibrosis (PMF) is a rare myeloproliferative neoplasm characterized by elevated platelet counts and fibrous tissues in the bone marrow. The JAK1/2 inhibitor (JAKi), ruxolitinib, has demonstrated efficacy in reducing splenic size, alleviating myelofibrosis-related symptoms, and improving overall survival.
Epstein-Barr virus-associated lymphoproliferative disease during ...
van Esser JW, van der Holt B, Meijer E, et al. Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell--depleted SCT.
Epstein-Barr-Virus-Related Lymphoproliferative Disorder in a
2024年3月20日 · In this report, we present the case of a 69-year-old woman diagnosed with EBV-positive diffuse large B-cell lymphoma (DLBCL) during PMF treatment with ruxolitinib. Additionally, we conducted a literature review of EBV-positive LPD …
EBV-driven B-cell lymphoproliferative disorders: from biology ...
2015年1月23日 · Here we review our current understanding of EBV-induced lymphomagenesis and focus on biology, diagnosis and management of EBV-associated B-cell lymphoproliferative disorders. Epstein–Barr...
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr virus–associated aggressive NK cell leukemia (EBV+ ANKL) is a rare NK cell malignancy that occurs most often in Asians and young to middle-aged adults. It sometimes evolves directly from other NK cell proliferative disorders such as, particularly in younger individuals, chronic active EBV infection (CAEBV). [1]
Case-report: EBV driven lymphoproliferative disorder associated with ...
We report a case of a 57 year old female with post-polycythemic myelofibrosis who was treated with Ruxolitinib. Approximately 9 weeks later she presented with a rapidly fatal, suspected EBV driven lymphoproliferative disorder in the CNS.
EBV + lymphoproliferative diseases: opportunities for leveraging EBV …
2022年2月17日 · EBV is associated with lymphoid neoplasms, according to the 2016 World Health Organization classification, including mature B-cell neoplasms, mature T- and NK-cell neoplasms, HL, and posttransplantation lymphoproliferative disorders. 30 Of the mature B-cell lymphomas, DLBCL is the most common lymphoma associated with EBV, and although endemic ...