Clinical translation of silica nanoparticles - Nature
2021年10月7日 · Mesoporous silica nanoparticles with pore sizes of 2–50 nm have beneficial properties, such as a large surface area (>1,000 m 2 g −1), and tunable shapes and sizes, making them an ideal...
Synthetic amorphous silica nanoparticles: toxicity, biomedical ... - Nature
2020年9月16日 · Silica condensation followed by SDA removal by solvent extraction or thermal treatment (calcination) creates an amorphous silica replica of the mesophase composed of periodic, hexagonal, cubic ...
Tetrandrine alleviates silicosis by inhibiting canonical and ... - Nature
2021年8月20日 · The NLRP3 (NLR family pyrin domain-containing 3) inflammasome has been established as a major proinflammatory receptor for sensing environmental danger, such as crystalline silica, and ...
Current status of silica-based nanoparticles as therapeutics and its ...
2022年12月22日 · Silica has an excellent biosafety profile and has been tested in several early phase clinical trials since 2012, demonstrating good tolerability and minimal reported side effects. In this review, we discuss the clinical development of silica nanoparticles to date and identify the gaps and potential pitfalls in its path to clinical translation.
Mesoporous Silica Particles as Drug Delivery Systems—The State …
2021年6月24日 · This seminal work initiated the dynamic development of research focused on the application of mesoporous particles as carriers in drug delivery systems. Silica has been approved by the FDA (The US Food and Drug Administration) as “Generally Recognized as Safe” (GRAS) and can also be used in cosmetics and as a food additive . Studies in a ...
Synthesis, nanocrystalline morphology, lattice dynamics and ... - Nature
4 天之前 · We demonstrate a hybrid nanocomposite combining mesoporous silica, p $$\hbox {SiO}_2$$ , as a host medium and guest lithium niobate $$\hbox {LiNbO}_3$$ nanocrystals embedded into tubular silica ...
Multifunctional Role of Silica in Pharmaceutical Formulations
2022年3月16日 · This review focuses on the multifunctional roles of silica in different pharmaceutical formulations including solid preparations, liquid drugs, and advanced drug delivery systems. For traditional solid preparations, it can improve compactibility and flowability, promote disintegration, adjust hygroscopicity, and prevent excessive adhesion.
Silica Nanoparticles: Morphology and Applications | SpringerLink
2021年10月22日 · Morphology-controlled nanomaterials have been leading groundbreaking technological discoveries. The biocompatibility of silica nanoparticles presents themselves as a critical asset for their use in biomedicine as nanocarriers in drug delivery and bioimaging....
Complex silica composite nanomaterials templated with DNA origami | Nature
2018年7月16日 · Genetically encoded protein scaffolds often serve as templates for the mineralization of biocomposite materials with complex yet highly controlled structural features that span from nanometres to...
Quercetin-Loaded Mesoporous Silica Nanoparticle–Based …
2022年11月29日 · Mesoporous silica nanoparticles (MSNPs) have been proposed as a potential approach for stabilizing the amorphous state of poorly water-soluble actives. This study aimed to improve the physiochemical characteristics of poorly water-soluble quercetin (QT) through a novel lyophilized formulation.