Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting
网页2019年1月26日 · Short-term rise in Ca 2+ levels, known as calcium transients, are believed to play an important role in mediating various neuronal development stages such as growth, migration, differentiation, survival and formation of …
Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and …
网页In this study, we assess the role of NCS-1 in breast cancer biology and drug response by altering the endogenous expression of this protein in MCF-7 and MB-231 cell lines. Additionally, we examined the clinical association between NCS-1 expression and survival in breast cancer patients.
Fastest-ever calcium sensors broaden the potential of neuronal
网页2023年3月15日 · This ability to measure neuronal activity by proxy — through flashes of light — revolutionized the field of neuroscience, and led to the identification of previously unknown dynamics in the...
Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and
网页Functional characterization of NCS-1 in neuronal model systems suggests that NCS-1 may influence oncogenic processes. To this end, the biological role of NCS-1 was investigated by altering its endogenous expression in MCF-7 and MB-231 breast cancer cells.
Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal …
网页2021年9月9日 · Here, we systematically investigated the functions of NCS1 in the brain. Using Golgi-Cox staining, we observed a reduction in dendritic complexity and spine density in the prefrontal cortex and the dorsal hippocampus of Ncs1−/− mice, which may underlie concomitantly observed deficits in memory acquisition.
Neuronal Calcium Sensor 1 (NCS1) Dependent Modulation of Neuronal …
网页This study focuses on neuronal calcium sensor 1 (NCS1), one member of the Ca2+ sensor family. NCS1 is a high affinity, low-capacity Ca2+ binding protein that is ubiquitously expressed, with the highest abundance in neuronal tissues .
Neuronal Calcium Sensor 1 is up‐regulated in response to stress …
网页2020年4月2日 · Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed Ca 2+-binding protein that promotes tumor aggressiveness by enhancing cell survival and metastasis. However, the underlying mechanism by which NCS1 contributes to increased tumor aggressiveness has yet to be identified.
Current Understanding of the Role of Neuronal Calcium Sensor 1 …
网页2019年2月4日 · Neuronal calcium sensor 1 (NCS-1) is a high-affinity calcium-binding protein and its ubiquitous expression in the nervous system implies a wide range of functions. To date, it has been implicated in regulation of calcium channels in both axonal growth cones and presynaptic terminals, pre- and …
网页Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed Ca2+-binding protein that promotes tumor aggressiveness by enhancing cell survival and metastasis. However, the underlying mechanism by which NCS1 contributes to increased tumor aggressiveness has yet to be identified. In this study, we aimed to determine.
Understanding the physiological roles of the neuronal calcium sensor ...
网页2012年1月23日 · Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca 2+ concentration are detected by Ca 2+ -binding proteins that can interact with and regulate target proteins to modify their function.