Oxime - Wikipedia
In organic chemistry, an oxime is an organic compound belonging to the imines, with the general formula RR’C=N−OH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. O-substituted oximes form a closely related family of compounds.
FDA-Approved Oximes and Their Significance in Medicinal Chemistry
2022年1月4日 · Oxime based cephalosporins are widely used drugs against bacterial infections and, among them, cefuroxime, ceftizoxime, cefpodoxime and cefmenoxime are FDA-approved oximes used against several bacterial infections (Figure 2). Their synthesis and pharmacokinetics will be discussed in this review.
Oximes - Definition, Structure, Properties along with Applications …
An oxime is a functional group consisting of a hydroxyl group bonded to the nitrogen atom of an imine. An oxime derived from an aldehyde is called an aldoxime and derived from ketone is called ketoxime.
Oxime | Organic Chemistry, Synthesis, Reactions | Britannica
Oxime, any of a class of nitrogen-containing organic compounds usually prepared from hydroxylamine and an aldehyde, a ketone, or a quinone. Oximes have the structure X\Y/C= N―OH, in which X and Y are hydrogen atoms or organic groups derived by removal of a hydrogen atom from an organic compound.
Amidoximes and Oximes: Synthesis, Structure, and Their Key Role …
2019年7月5日 · An oxime is a compound belonging to imines family (RR′C = NOH). If R is an alkyl or an aryl group, R′ may be a hydrogen atom (aldoxime) or an alkyl/aryl group (ketoxime) ( Figure 1 ). These compounds are usually synthesized by the addition of hydroxylamine on an aldehyde or a ketone [ 25 , 49 , 50 ].
Oximes: Novel Therapeutics with Anticancer and Anti …
2021年5月22日 · Oxime groups have been successfully introduced into a large number of therapeutic leads for the development of kinase inhibitors with anticancer and anti-inflammatory activities. The kinase selectivity of oximes does not appear to be due to the oxime group.
Oxime - an overview | ScienceDirect Topics
The reduction of oximes or oxime ethers and esters to primary amines is a useful synthetic transformation that is used as a substitute for direct reductive amination to convert ketones or aldehydes to primary amines. The reaction involves reduction of …
II. Oximes - Chemistry LibreTexts
2022年9月14日 · Electron transfer provides another means for generating a ring-forming radical from an oxime ether. The electron donor in such reactions typically is samarium (II) iodide and the electron acceptor often is an oxime ether containing a halogen atom.
FDA-Approved Oximes and Their Significance in Medicinal Chemistry …
2022年1月4日 · Oxime based cephalosporins have emerged as an important class of drugs with improved efficacy and a broad spectrum of anti-microbial activity against Gram-positive and Gram-negative pathogens. Among the several oxime based derivatives, cefuroxime, ceftizoxime, cefpodoxime and cefmenoxime are the FDA approved oxime-based antibiotics.
Metal-Involving Synthesis and Reactions of Oximes
2017年10月9日 · In this review, we summarize recent advances in the area of metal-involving reactions of oximes and discuss synthetic routes leading to oxime derivatives (section 2), functionalization of oxime moiety (section 3), ligation of the oxime group to a metal center that results in transformations of a side-chain of oxime species (section 4), and ...