Primordial germ cell migration - Wikipedia
Primordial germ cell (PGC) migration is the process of distribution of primordial germ cells throughout the embryo during embryogenesis. Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes. [2] .
Mechanisms guiding primordial germ cell migration: strategies …
Primordial germ cell (PGC) migration provides a useful system for studying a group of individually migrating cells in vivo. PGC migration in all species...
Primordial Germ Cell Development - Embryology
4 天之前 · Here, we review the two main mechanisms of PGC specification, induction, and preformation, in the context of four model vertebrate species: mouse, axolotl, Xenopus frogs, and zebrafish.
Mechanisms guiding primordial germ cell migration: strategies …
Primordial germ cell (PGC) migration provides a useful system for studying a group of individually migrating cells in vivo. PGC migration in all species follows similar steps: initiation of polarity and directed migration, regulated migration by attractive and repulsive cues, and termination of migration at the site of gonad formation.
Derivation of human primordial germ cell-like cells in an ... - Nature
2024年1月2日 · Here, we report the induction of hPGC-like cells (hPGCLCs) in a bioengineered human pluripotent stem cell (hPSC) culture that mimics peri-implantation human development. In this culture,...
Primordial Germ Cell Specification from Embryonic Stem Cells
2008年12月24日 · The investigation of primordial germ cell (PGC) specification is the first essential step in the process of elucidating the mechanisms involved in the development of a germ cell lineage. However, significant difficulties exist with regard to research into the process of PGC specification in vivo .
Determining the potency of primordial germ cells by injection into ...
Sepulveda-Rincon et al. present a detailed investigation of the potency of primordial germ cells (PGCs). Following injection into early mouse embryos, PGCs can display properties akin to naive pluripotent cells, but they do not functionally contribute to later embryogenesis, supporting the notion that PGCs exhibit a latent form of pluripotency.
Generation of germ cells from pluripotent stem cells in mammals
2017年12月10日 · Primordial germ cells (PGCs), the early embryonic precursors of the germ cell lineage, differentiate into oocytes in females or sperm in males. To ensure that the appropriate epigenetic information is transmitted across generations, PGCs undergo extensive epigenetic modifications, including chromatin modifications and global erasure of DNA ...
Primordial germ-cell development and epigenetic reprogramming in ...
Primordial germ cells (PGCs) are the embryonic precursors of the gametes and represent the founder cells of the germline. Specification of PGCs is a critical divergent point during embryogenesis. Whereas the somatic lineages will ultimately perish, cells of the germline have the potential to form a …
Efficient differentiation of human primordial germ cells through ...
This manuscript describes a powerful tissue culture model to study the early embryonic development of human primordial germ cells (PGC), the precursors of eggs and sperm. The study dissects the signaling pathways that direct the formation of PGC and provides important clues as to the origins of these cells during development.
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