The role of PINK1–Parkin in mitochondrial quality control
网页2024年10月2日 · In the pathway, PINK1 is the damage sensor, probing the integrity of the mitochondrial import pathway, and activating Parkin when import is blocked. Parkin is the effector, selectively marking ...
线粒体自噬通路 (Mitophagy pathway) - Abcam中文官网
网页线粒体自噬是指通过自噬体选择性地去除受损线粒体，随后通过溶酶体对其进行分解代谢。通过我们的交互通路了解 PINK1、Parkin 和自噬机制在线粒体自噬通路中的作用，并阅读包含 Abcam 完整产品的弹出窗口和产品列表，确定可促进您研究的关键试剂。
Pink1/Parkin deficiency alters circulating lymphocyte ... - Nature
网页1 天前 · Pink1/Parkin deficiency induces changes in the circulating lymphocyte populations, namely increased CD4 + T cells and decreased CD8 + T cells and B cells. Loss of Pink1/Parkin leads to elevated ...
线粒体自噬的分子机制，你都清楚了吗？ - 知乎专栏
网页2023年11月20日 · 泛素依赖途径的关键蛋白是PINK1和Parkin，因此也被称为 PINK1–Parkin介导的线粒体自噬途径（PINK1–Parkin mediated mitophagy）。. PINK1是一种位于去极化线粒体上的丝氨酸/苏氨酸激酶，而Parkin是一种E3泛素连接酶，可催化泛素转移到线粒体底物。. 稳态条件下，胞质中的 ...
PINK1/parkin通路调控线粒体自噬机制的研究进展
网页大量研究表明，帕金森病相关基因PINK1和parkin可通过线粒体自噬参与并维持线粒体功能。PINK1与parkin能协同特异性识别损伤的线粒体，PINK1作为线粒体质量调控的探测器被活化，此过程中泛素化酶和去泛素化酶对维持parkin活性及线粒体自噬的效率有重要作用。
Mechanism of parkin activation by PINK1 - Nature
网页2018年6月6日 · Parkin is autoinhibited, and requires activation by PINK1, which phosphorylates Ser65 in ubiquitin and in the parkin ubiquitin-like (Ubl) domain. Parkin binds phospho-ubiquitin, which...
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
网页2020年11月9日 · PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) signalling play a key role in mitophagy and mitochondrial motility and size. PINK1 accumulates at the OMM in response to a reduction in mitochondrial ΔΨm caused by damage/dysfunction.
PINK1: A Bridge between Mitochondria and Parkinson’s Disease
网页2021年4月21日 · Mutations in several of these PARK genes also cause mitochondrial dysfunctions, namely PINK1 (PARK6) 5 and Parkin (PARK2) [60,61]. PINK1 mutations cause autosomal recessive PD and certain clinical features are more common in patients with PINK1 mutations.
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
网页2020年11月9日 · Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitoc ….
Mechanism of Parkin activation by PINK1 - PMC - National …
网页Parkin is autoinhibited, and requires activation by PINK1, which phosphorylates Ser65 in ubiquitin and in the Parkin ubiquitin-like (Ubl) domain. Parkin binds phospho-ubiquitin, which enables efficient Parkin phosphorylation, however the enzyme remains autoinhibited with an inaccessible active site 5, 6.