PARKINSON'S DISEASE - Neuropathology
The core pathology of Parkinson's PD primarily affects the dopamine-producing neurons of the substantia nigra (SN). These neurons are distinguished by their extensive and highly branched axons, numerous synapses, and high energy demands.
Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis
2018年12月21日 · Parkinson’s disease (PD) is a common neurodegenerative disorder. While a number of non-motor manifestations arise, the typical clinical features involve a movement disorder consisting of bradykinesia, resting tremor, and …
Parkinson’s Disease and Parkinsonism: Neuropathology - PMC
Parkinson’s disease (PD) is a progressive neurological disorder defined by a characteristic clinical syndrome by bradykinesia, tremor, rigidity, and postural instability. There are a large number of different disorders that can have some or all of these clinical features, and the clinical syndrome is referred to as “parkinsonism.”
Neuropathology of Parkinson disease - PubMed
Introduction: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD.
The genetics and neuropathology of Parkinson’s disease - PMC
There has been tremendous progress toward understanding the genetic basis of Parkinson’s disease and related movement disorders. We summarize the genetic, clinical and pathological findings of autosomal dominant disease linked to mutations in SNCA, LRRK2, ATXN2, ATXN3, MAPT, GCH1, DCTN1 and VPS35.
Neuropathology of Parkinson disease - ScienceDirect
2018年1月1日 · Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD.
Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis
Several processes have been implicated in PD, including mitochondrial dysfunction, defective protein clearance mechanisms, and neuroinflammation, but the way in which these factors interact...
Parkinson's disease and parkinsonism: neuropathology
2012年8月1日 · Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable associated extrapyramidal signs and symptoms, is accompanied by degeneration of the nigrostriatal dopaminergic system, with neuronal loss and reactive gliosis in the substantia nigra found at autopsy.
Pathology of Parkinson’s disease | Molecular and chemical neuropathology
In Parkinson’s disease (PD), in addition to degeneration of the nigrostriatal dopaminergic pathway, a variety of neuronal systems are involved, causing multiple neuromediator dysfunctions that account for the complex patterns of functional deficits.
Neuropathology of Parkinson’s Disease and Related Syndromes
1992年5月1日 · Parkinsonism is often the expression of a neuro-degeneration that may have other clinical presentations. Pick’s disease may present with predominant dementia or parkinsonism, and a possibility exists that the pathology of corticobasal degeneration might also present with parkinsonism or dementia.