Plasmodium sporozoites on the move: Switching from cell …
Plasmodium sporozoites, the mosquito‐transmitted forms of the malaria parasite, traverse multiple cells during their migration from the skin to the liver, before switching to productive invasion of a suitable hepatocyte for replication. Cell traversal and productive invasion are functionally independent processes that require proteins ...
The silent path to thousands of merozoites: the Plasmodium liver …
Nov 1, 2006 · Plasmodium sporozoites are deposited in the skin of their vertebrate hosts through the bite of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and travel in the...
Plasmodium sporozoites can invade hepatocytic cells …
Jul 5, 2018 · After their inoculation into the skin by infected Anopheles mosquitoes, Plasmodium sporozoites rapidly migrate to the liver using gliding motility and cell traversal activity. Once in the liver, they first traverse hepatocytes before invading them and developing into exo-erythocytic forms (EEFs), surrounded by a parasitophorous vacuole membrane ...
Malaria-Causing Parasite Manipulates Liver Cells to Survive
May 22, 2018 · After arriving at the liver, Plasmodium forces its way into liver cells, stealing a bit of the cell membrane to form a small pouch inside the cell. This pouch, called a vacuole, provides a safe harbor while the parasite grows and divides, stealing nutrients and proteins from the host cell along the way.
The Plasmodium liver-stage parasitophorous vacuole: A front …
Jan 1, 2018 · Before entering the symptomatic infection of red blood cells, Plasmodium parasites undergo an obligatory and clinically silent developmental phase in the liver, which constitutes an ideal target for disease prevention (Prudencio et al., 2006, Rodrigues et al., 2012).
Migration of Plasmodium Sporozoites Through Cells Before …
Jan 5, 2001 · After Plasmodium sporozoites are injected into the mammalian host by mosquitoes, hepatocyte infection is the next obligatory step. In time-lapse video microscopy observations, sporozoites appeared to enter and exit hepatocytes rapidly [ (Fig. 1 and Web movie 1) (1)] as previously described for macrophages (2).
Targeting Plasmodium host cells: survival within hepatocytes
Oct 1, 2004 · Upon entering their host, Plasmodium sporozoites travel directly to the liver. Once there, they migrate through several hepatocytes before they infect a final one.
Plasmodium sporozoites on the move: Switching from cell …
Sporozoites migrate through the dermis, enter the bloodstream, and rapidly traffic to the liver. They cross the liver sinusoidal barrier and traverse several hepatocytes before switching to productive invasion of a final one for replication inside a parasitophorous vacuole.
Autophagy protein Atg7 is essential for maintaining malaria …
Dec 23, 2024 · Here, we show that the Plasmodium berghei autophagy-related E1-like enzyme Atg7 is expressed in the blood, sporozoites, and liver stages, localized to the parasite cytosol, and is essential for the localization of Atg8 on the membrane and the development of parasite blood and liver forms. We found that depleting Atg7 abolishes Atg8 lipidation ...
Chronicle of a death foretold: Plasmodium liver stage parasites …
Jan 1, 2012 · During liver stage development, Plasmodium merozoites remain within their host cell for a comparatively long time period after PVM rupture and therefore might have evolved inhibitors that slow down cell death and create a shift toward an immunologically silent outcome.