Polyol pathway - Wikipedia
The polyol pathway is a two-step process that converts glucose to fructose. [1] In this pathway glucose is reduced to sorbitol, which is subsequently oxidized to fructose. It is also called the sorbitol-aldose reductase pathway. The pathway is implicated in diabetic complications, especially in microvascular damage to the retina, [2] kidney, [3 ...
Biochemistry, Polyol Or Sorbitol Pathways - StatPearls - NCBI Bookshelf
2022年11月14日 · The sorbitol or polyol pathway is a two-step metabolic pathway that converts glucose into fructose. This pathway is thought to play a prominent role in explaining the pathogenesis of complications in patients with end-stage diabetes.
Polyol Pathway - an overview | ScienceDirect Topics
Polyol pathway is a metabolic pathway where a part of excess glucose gets metabolized to sorbitol which is then converted to fructose. Aldose reductase (AR) is the key and rate-limiting enzyme in polyol pathway, and galactose and glucose are substrates to this enzyme which are reduced to galactitol and sorbitol, respectively.
多元醇旁路激活 - 百度百科
多元醇旁路激活，被激活的醛糖还原酶把葡萄糖还原为 山梨醇 ，造成细胞内山梨醇堆积，导致细胞生理机能障碍；同时激活 蛋白激酶c 使胶原合成增多， 肾小球基底膜 增厚，通透性增加。 动物实验中用 醛糖还原酶抑制剂 可消除这些现象，减少尿蛋白。
Polyol Pathway - an overview | ScienceDirect Topics
Polyol pathway is a metabolic pathway where a part of excess glucose gets metabolized to sorbitol which is then converted to fructose. High blood glucose levels increase activity in the polyol pathway. In the polyol pathway, glucose is reduced to sorbitol by aldose reductase (AR), leading to depletion in cellular stores of NAD(P)H [35]. Reduced ...
The polyol pathway is an evolutionarily conserved system for
2022年6月10日 · The polyol pathway is a two-step metabolic pathway, in which glucose is reduced to sorbitol then converted to fructose . Although physiological functions of this pathway remain elusive, the genes encoding polyol pathway enzymes are conserved from yeasts to humans, suggesting that it plays an important as yet unknown role across species.
The Polyol Pathway as a Mechanism for Diabetic Retinopathy: …
2007年7月30日 · The polyol pathway is, at first glance, a dream target when aiming to develop drugs for prevention of the complications of diabetes. The rate-limiting enzyme of the pathway, AR, acts on the glucose molecule, and therefore at the most upstream possible site in the cascade of glucose toxicity.
The polyol pathway and nuclear ketohexokinase A signaling drive ...
2024年1月10日 · The hyperglycemia-induced acquisition of metastatic potential was mediated by increased fructose derived from the polyol pathway, which stimulated the nuclear ketohexokinase-A (KHK-A) signaling...
Recent Progress on Fructose Metabolism—Chrebp, Fructolysis, and Polyol …
2023年4月5日 · The polyol pathway converts excess glucose into sorbitol and fructose. In diabetic conditions, the polyol pathway is activated and accelerates diabetic microvascular complications such as diabetic neuropathy [93,94,95].
The Polyol Pathway and Diabetic Retinopathy | SpringerLink
The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol, which is then converted to fructose. Several biochemical features and a large body of data implicate the polyol pathway as a plausible and important contributor to diabetic retinopathy and other complications of diabetes.
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