Primordial germ cell migration - Wikipedia
Primordial germ cell (PGC) migration is the process of distribution of primordial germ cells throughout the embryo during embryogenesis. Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes. [2] .
Primordial Germ Cell Development - Embryology
4 天之前 · Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie stage 23 "Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Mechanisms guiding primordial germ cell migration: strategies …
Primordial germ cell (PGC) migration provides a useful system for studying a group of individually migrating cells in vivo. PGC migration in all species follows similar steps: initiation of...
Cell发表汤富酬、乔杰团队关于人类原始生殖细胞的重要成果
2015年6月5日 · 该项工作系统、深入地研究了人类多个发育阶段原始生殖细胞（PGC）的转录组和DNA甲基化组，发现人类原始生殖细胞不同于小鼠原始生殖细胞的关键独特特征。 人类原始生殖细胞产生于胚胎发育的早期，是发育为成熟的精子和卵细胞的前体细胞，精卵结合后会发育成新的个体、并将遗传物质传递给下一代以维持种族的延续。...
Derivation of human primordial germ cell-like cells in an …
2024年1月2日 · Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They transmit genetic and epigenetic information across generations.
Primordial Germ Cell - an overview | ScienceDirect Topics
Primordial germ cells (PGCs) are diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. Human embryonic germ (hEG) cells, also a form of stem cell, are isolates of PGCs from the developing gonadal ridge of 5 ...
Primordial Germ Cells and Sex Determination in Mammals
In this section, we consider how mammalian primordial germ cells arise, how the sex of a mammal is determined, and how sex determination dictates whether the primordial germ cells develop into sperm or eggs.
Principles of early human development and germ cell program …
Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development 1. Using in vitro models of hPGC induction 2–4, recent studies suggest striking mechanistic differences in specification of human and mouse PGCs 5.
Primordial Germ Cell Specification in Vertebrate Embryos
2021年9月16日 · The differentiation of primordial germ cells (PGCs) occurs during early embryonic development and is critical for the survival and fitness of sexually reproducing species. Here, we review the two main mechanisms of PGC specification, induction, and preformation, in the context of four model vertebra …
Primordial Germ Cell Specification from Embryonic Stem Cells
2008年12月24日 · The investigation of primordial germ cell (PGC) specification is the first essential step in the process of elucidating the mechanisms involved in the development of a germ cell lineage. However, significant difficulties exist with regard to research into the process of PGC specification in vivo .