RNA splicing - Wikipedia
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre- mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and …
Genetic control of RNA splicing and its distinct role in complex …
2022年8月18日 · In this study, we aimed to investigate the genetic control of RNA splicing by generating the largest collection of sQTLs to date and describing their role in complex trait variation.
RNA Splicing by the Spliceosome - PubMed
2020年6月20日 · The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we aim to make this mechanism understandable and provide several videos of …
Structures of the human spliceosomes before and after release …
2019年2月6日 · Pre-mRNA splicing is executed by the spliceosome, which has eight major functional states each with distinct composition. Five of these eight human spliceosomal complexes, all preceding exon ...
Genetic control of RNA splicing and its distinct role in complex …
Our study demonstrates the distinct role of most sQTLs in the genetic regulation of transcription and complex trait variation.
Spliceosome structure and function - PubMed
2011年7月1日 · Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and RNP networks, which serve to align the reactive groups of the pre-mRNA for catalysis, are formed and repeatedly rearranged during ….
Structural basis of branching during RNA splicing - Nature
2023年12月6日 · Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome structures have led to competing models for the recognition of the invariant ...
Molecular Mechanisms of pre-mRNA Splicing through Structural …
The components of the spliceosome constitute five distinct classes: the uridine-rich RNPs (U1, U2, U4, U5, and U6 snRNPs), the NineTeen complex (NTC) and the NTC-related complex (NTR), the splicing factors, the RNA-dependent ATPase/helicases, and other regulatory and/or auxiliary proteins such as kinases/phosphatases and peptidyl prolyl ...
RNA structure and splicing regulation - PMC - National Center for ...
As an example of RNA structures ruling the most complex spliced gene, Jin et al. (Chapter 3) discuss the identification, evolution and regulatory roles of RNA secondary structures in regulation of alternative splicing of the mutually exclusive exons of the Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) gene .
RNA Splicing: A New Paradigm in Host–Pathogen Interactions
2019年4月5日 · A matured mRNA involves careful removal of introns and stitching together of exons through a process called RNA splicing. By omitting or retaining specific exons (through alternative splicing), the sequence and therefore structure, function, and stability of the translated protein products could be altered.