Inhibition of S6K lowers age-related inflammation and increases ...
网页2024年2月27日 · Here we show that activation of S6K specifically in Drosophila fat-body blocked extension of lifespan by rapamycin, induced accumulation of multilamellar lysosomes and blocked age-associated ...
S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation …
网页2021年4月17日 · We show that the perturbation of autophagic flux in S6K1-deficient cells did not stem from impaired lysosomal function. Instead, the absence of S6K1 abolished stress-induced tubulin acetylation and disrupted the acetylated microtubule network, in turn impairing the autophagosome-lysosome fusion.
Ribosomal S6 kinase 1 regulates inflammaging via the ... - Nature
网页2024年8月29日 · Inhibition of S6 kinase 1 (S6K1) extends lifespan in mice, but the underlying mechanisms are not fully understood. Here Gallage et al. show that reduction of S6K signaling diminishes inflammation...
S6K is a morphogenic protein with a mechanism involving …
网页2014年12月15日 · The effects of S6K on cell shape recapitulate the process of malignant transformation. The diversity of the cell's response to S6K in several, unrelated cell types indicates the existence of a common, underlying mechanism that involves actin dynamics.
Beyond controlling cell size: functional analyses of S6K in ...
网页2022年7月25日 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been canonically assigned for cell...
Nuclear Export of S6K1 II Is Regulated by Protein Kinase CK2 ...
网页Ribosomal S6 kinases (S6Ks) are principal players in the regulation of cell growth and energy metabolism. Signaling via phosphatidylinositol 3-kinase and mammalian target of rapamycin pathways mediates the activation of S6K in response to various mitogenic stimuli.
Mis-regulation of mammalian target of rapamycin (mTOR
网页2014年6月13日 · Physiologic albumin concentrations activated the PI3K/mTORC2/PKB/mTORC1/S6 kinase (S6K) pathway, but pathophysiologically high albumin concentrations overactivated mTORC1 and inhibited mTORC2 activity. This control process involved the activation of ERK1/2, which promoted the inhibition of TSC2 and activation of S6K.
S6K in tube formation induced by albumin. A: Induction of.
网页A: Induction of phosphorylation of S6K by albumin. Phosphorylation of S6K was examined in whole cell lysate in Western blot. B: BSA-stimulated tube formation and inhibition by rapamycin (200...
Inhibition of S6K lowers age-related inflammation and increases ...
网页2024年2月27日 · Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are unclear. Here we show that activation of S6K specifically in Drosophila fat-body blocked extension of lifespan by …
The p85 isoform of the kinase S6K1 functions as a secreted ... - AAAS
网页2018年3月27日 · Here, we demonstrated that recombinant p85 S6K directly enhances growth and migration in cultured and xenografted breast cancer cells, highlighting a potential strategy of targeting secreted p85 with specific antibodies to combat abnormal p85 S6K1-driven breast cancer growth and lung metastasis.
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