Spermine - Wikipedia
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.
The function of spermine - PubMed
This review describes these alterations and focuses on the roles of spermine which may contribute to these phenotypes including reducing damage due to reactive oxygen species, protection from stress, permitting correct current flow through inwardly rectifying K(+) channels, controlling activity of brain glutamate receptors involved in learning ...
Spermine | C10H26N4 | CID 1103 - PubChem
Spermine is a spermidine -derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
Polyamines: Functions, Metabolism, and Role in Human Disease …
Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses.
Spermine - an overview | ScienceDirect Topics
Spermine, so named as a polyamine that was first discovered in semen, is present in seminal plasma at concentrations of 50–350 mg/dL and imparts a unique odor to semen. The prostate gland has the highest concentration of spermine in the human body and is the primary source of this polyamine in seminal plasma.
Spermine - an overview | ScienceDirect Topics
Spermine is an endogenous polyamine that is produced in increased amounts following ischemia due to the enhanced activity of ornithine decarboxylase. It has been found to have a potentiating effect on the activities of ASICs and exacerbates ischemic neuronal injury by sensitizing ASIC1a to …
The Potential Role of Spermine and Its Acetylated Derivative in …
Numerous studies have reported the level of spermine in different body fluids and organ tissues in patients with different types of cancers. Currently, the role and the underlying mechanisms of spermine in cancer development and progression are still under investigation.
Spermine Synthesis Is Required for Normal Viability, Growth, …
Spermidine is essential for viability in eukaryotes but the importance of the longer polyamine spermine has not been established. Spermine is formed from spermidine by the action of spermine synthase, an aminopropyltransferase, whose gene (SpmS) is …
The function of spermine - Pegg - 2014 - IUBMB Life - Wiley …
2014年1月6日 · Spermine is the most strongly basic polyamine and the great majority of the cellular spermine is bound to acidic sites on macromolecules. Release of spermine from these sites is likely to induce the polyamine back-conversion/catabolic pathways that generate spermidine (Fig. 1A).
Spermine in Sperm: Exploring its Role and Function
2023年8月19日 · Spermine is a polyamine compound found in the human male reproductive system. It plays a crucial role in sperm function, including sperm maturation and motility. Spermine helps stabilize DNA structure, reduce oxidative damage, and maintain the …
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