Novel role of macrophage TXNIP-mediated CYLD–NRF2
Sep 1, 2022 · We demonstrated that macrophage TXNIP deficiency controlled STING-mediated TBK1 function and alleviated IR-induced hepatocellular injury by regulating the cylindromatosis (CYLD)–NADPH oxidase 4 (NOX4) axis.
Cell Reports丨衣康酸 4-辛酯通过阻断棕榈酰化来限制 STING 激活
Aug 31, 2023 · The cyclic guanosine monophosphate adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) axis plays a vital role in defending foreign pathogens and maintaining immune homeostasis.
The interaction between STING and NCOA4 exacerbates lethal …
Jul 28, 2022 · Our findings uncover a novel mechanism by which the interaction between STING and NCOA4 regulates innate immune response and ferroptosis, which can be reversed by HET0016, providing mechanistic and promising targets insights into sepsis.
Deletion of stimulator of interferons genes aggravated cardiac ...
Dec 1, 2024 · Results showed that STING knockout increased the protein levels of Acetylated superoxide-dismutase-2 (Ac-SOD2) and NADPH oxidase 4 (NOX4) in aged hearts (Fig. 6 A–C). Moreover, increased oxidative stress has also been evidenced by increased malondialdehyde (MDA) level ( Fig. 6 D) as well as reduced antioxidants MnSOD ( Fig. 6 E) and GSH-Px ...
Cell Reports丨衣康酸 4-辛酯作为代谢物衍生物通过 STING 的烷基 …
Mar 12, 2023 · In support of this, our previous study demonstrated that the stimulator of interferon genes (STING) signaling platform functions as a hub in macrophage immunity and has a profound impact on the prognosis of sepsis. Interestingly, we fi
Novel role of macrophage TXNIP-mediated CYLD ... - PubMed …
We demonstrated that macrophage TXNIP deficiency controlled STING-mediated TBK1 function and alleviated IR-induced hepatocellular injury by regulating the cylindromatosis (CYLD)–NADPH oxidase 4 (NOX4) axis.
STING antagonist-loaded renal tubule epithelial cell-mimicking ...
Apr 1, 2024 · Here, STING antagonist-loaded renal tubule epithelial cell membrane-coated nanoparticles (SNP@TEC) are developed to ameliorate AKI by orchestrating innate and adaptive immunity. As the reservation of cell membrane αV integrin, biomimetic SNP@TEC are able to target renal tubules via homotypic tropism.
Full article: IFN-γ activates the tumor cell-intrinsic STING pathway ...
Stimulator of interferon genes (STING) pathway activation predicts the effectiveness of targeting the PD-1/PD-L1 axis in lung cancer. Active IFN-γ signaling is a common feature in tumors that respond to PD-1/PD-L1 blockade. The connection between IFN-γ and STING signaling in cancer cells has not been documented.
Nature新热点分享：干扰素刺激因子（STING） - 知乎专栏
Nov 3, 2022 · sting是体内固有免疫反应的关键信号转导分子,被外源性dna触发, 在调节体内自发性抗肿瘤免疫反应产生过程发挥重要功能。 cGAS-STING通路与其他几种先天免疫信号机制不同的一个显著特征是，它的激活是由DNA触发的，因此缺乏任何病原体特异性属性。
Iron derived from NCOA4-mediated ferritinophagy causes cellular ...
Nov 18, 2023 · NCOA4, a cargo receptor for ferritinophagy, mediates degradation of ferritin and contributes to iron accumulation. Besides, we found that iron overload leads to mitochondrial dysfunction. As a...