Telomere - Wikipedia
At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA, and base pairing to one of the two strands.
Telomeres: The Role of Shortening in Cancer and Aging, How to …
2019年3月8日 · Telomeres are small structures that protect the ends of your chromosomes. Over time, they tend to get shorter. We’ll dive into the recent research surrounding telomere shortening, cancer, and...
Telomere
4 天之前 · A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a cell divides, the telomeres become slightly shorter.
Telomeres: Definition, Structure, Shortening and Role in Ageing
What does telomere do in the body? The primary function of telomeres is to prevent the loss of base pairs at chromosomal ends. They also prevent the chromosomes from fusing with each other.
Biochemistry, Telomere And Telomerase - StatPearls - NCBI Bookshelf
2022年12月11日 · A telomere structure consists of repeats of non-coding nitrogenous bases (5'-TTAGGG-3'). In mammals, telomeres are highly conserved, indicating that this nuclear sequence remains relatively unchanged throughout evolutionary biology. [1]
What is a telomere? - YourGenome
Telomere biology is incredibly important in human cancer and scientists are working hard to understand the best way to exploit their knowledge of it to advance the treatment of cancer. Find out more about chromosomes here.
Telomere | DNA Segment, Chromosome Protection | Britannica
telomere, segment of DNA occurring at the ends of chromosomes in eukaryotic cells (cells containing a clearly defined nucleus). Telomeres are made up of repeated segments of DNA that consist of the sequence 5′-TTAGGG-3′ (in which T, A, and G are the bases thymine, adenine, and guanine, respectively).
Telomeres - Structure, Function, and Regulation - PMC
Understanding the mechanisms that regulate telomere homeostasis and the factors that contribute to telomere dysfunction should aid us in developing diagnostic and therapeutic tools for these diseases. Keywords: telomere, telomerase, telosome, telomere maintenance, end protection, extra-telomeric, telomere dysfunction. Introduction
Telomeres and telomerase: three decades of progress
2019年2月13日 · Three decades ago, the classic view was that telomeres protected the natural ends of linear chromosomes and that telomerase was a specific telomere-terminal transferase necessary for the ...
Telomeres: History, Health and Hallmarks of Aging - PMC
This review provides an overview of the history and current state of telomere research, highlights mechanistic connections between telomere dysfunction and aging hallmarks, and examines the seemingly pervasive roles of telomeres and telomerase in driving hallmarks of aging, progeria syndromes, and common age-associated diseases such as ...