Regulated cell death (RCD) in cancer: key pathways and targeted ...
2022年8月13日 · Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the form of cell death that can be regulated by a variety of biomacromolecules, which is distinctive...
What Happens to Tumor Cells After They Are Killed? - LWW
2017年12月25日 · Researchers from Harvard Medical School, Boston, and the Institute for Systems Biology, Seattle, have discovered that the remains of tumor cells killed by chemotherapy or other cancer treatments can actually stimulate tumor growth by …
How cell death shapes cancer | Cell Death & Disease - Nature
2015年3月5日 · Though cells can commit suicide by multiple ways, most cell death in vertebrates is mediated by the mitochondrial (intrinsic) pathway that is initiated by a plethora of signals, such as DNA...
The unfolding story of dying tumor cells during cancer treatment
2023年2月27日 · In this review, we provide an account on the cell death modes and the relationship between dying tumor cells with tumor immune microenvironment during cancer treatment, focusing on immunotherapy, from mechanistic standpoint to emerging limitations and future directions.
Comparing the effects of different cell death programs in tumor ...
2018年10月19日 · Several signaling pathways have been defined for specific forms of cell death, including apoptosis and necroptosis. Apoptosis is engaged during development and tissue homeostasis, while...
Mechanisms and cross-talk of regulated cell death and their …
2024年11月29日 · Mutations or defects in cell death-related genes block the elimination of abnormal cells and enhance the resistance of malignant cells to chemotherapy. Therefore, the investigation of cell death mechanisms enables the development of drugs that directly induce tumor cell death.
Targeting cell death pathways for cancer therapy: recent …
2022年12月8日 · In this section, we explore various types of cell death in the TME and show how the interaction of host immune cells with these cells affects tumor progression and cancer treatment. Cancer cell death influences immune cell infiltration into the TME
Targeting cell death pathways for cancer therapy: recent
2022年12月8日 · This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target for …
Cell death, therapeutics, and the immune response in cancer - Cell …
2023年2月23日 · Neoplastic cell death is the primary goal of most cancer therapeutics, and the myriad pathways through which regulated cell death (RCD) can occur are becoming increasingly clear. Forms of RCD are classified according to their morphotypes into (i) type I cell death or apoptosis, (ii) type II cell death or autophagy, and (iii) type III cell death ...
Tumor Cell Death, Autophagy, and Immunity - PMC
It shows that the process of autophagy is critical to the anti-tumor immune response elicited by dying transplantable tumor cells. It thus implicates the process of autophagy as a critical link between effective chemotherapy and the host-derived anti-cancer immune responses observed in preclinical models.