Yoda 1 | Piezo1激动剂 | MCE - MCE-生物活性分子大师
网页2015年9月23日 · Yoda 1 是一种有效的选择性 Piezo1 激动剂。 Yoda 1 激活纯化的 Piezo1 通道。 Yoda 1 能有效抑制表皮生长因子 (EGF) 诱导的巨胞饮。 Yoda 1 增强 Ca 2+ 内流，随后激活钙激活钾通道 KCa3.1 和抑制 Rac1 激活。 MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务. Yoda 1 Chemical Structure. CAS No. : 448947-81-7. or 大包装询价. * Please select Quantity before adding items. Customer Review. …
Yoda1 - Wikipedia
网页Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.
A mechanism for the activation of the mechanosensitive Piezo1 …
网页2019年10月3日 · Here, using a combination of all-atom molecular dynamics simulations, calcium imaging and electrophysiology, we identify an allosteric Yoda1 binding pocket located in the putative mechanosensory...
Chemical activation of the mechanotransduction channel Piezo1
网页2015年5月22日 · Characterization of Yoda1 in artificial droplet lipid bilayers showed that Yoda1 activates purified Piezo1 channels in the absence of other cellular components. Our studies demonstrate that Piezo1 is amenable to chemical activation and raise the possibility that endogenous Piezo1 agonists might exist.
Piezo1 is a mechanically activated ion channel and mediates
网页2018年4月30日 · In pancreatic acinar cells, Yoda1 stimulates calcium influx and induces calcium-dependent pancreatic injury. Finally, selective acinar cell-specific genetic deletion of Piezo1 protects mice...
Mechanically activated ion channel Piezo1 modulates macrophage ...
网页2021年5月31日 · We found that Yoda1-mediated channel activation resulted in significantly enhanced F-actin mean intensity compared to DMSO controls (Fig. 5a).
Chemical activation of the mechanotransduction channel Piezo1
网页2015年5月22日 · In this study, we screened ~3.25 million compounds using a cell-based fluorescence assay and identified a synthetic small molecule we termed Yoda1 that acts as an agonist for both human and mouse Piezo1. Functional studies in cells revealed that Yoda1 affects the sensitivity and the inactivation kinetics of …
Yoda1’s energetic footprint on Piezo1 channels and its …
网页2022年7月7日 · The presence of Yoda1 alters single-channel dwell times and macroscopic kinetics consistent with a dual and reciprocal energetic modulation of open and shut states. Critically, we further discovered that the electrophysiological effects of Yoda1 depend on membrane potential and temperature, two other Piezo1 modulators.
PIEZO1 mediates a mechanothrombotic pathway in diabetes
网页2022年1月5日 · Activating Piezo1 using Yoda1 in neutrophils caused chromatin swelling, secretion of neutrophil elastases , and a significant increase in cell-free double-stranded DNA (dsDNA) (P = 0.04) , consistent with NETosis. Our results indicate that Piezo1 can be triggered via external pressure to induce NETosis, potentially contributing to neutrophil ...
小分子 Yoda1 激活机械敏感 Piezo1 通道的机制。,Nature …
网页2019年10月3日 · 我们的结果提出了一个模型，其中 Yoda1 作为分子楔子，促进力诱导的构象变化，有效降低通道激活的机械阈值。 Piezo1 通道中变构激动剂结合位点的识别将为未来具有临床价值的 Piezo 调制器的合理设计铺平道路。