Mimotope - Wikipedia
Vaccines utilizing mimotopes are being developed. Mimotopes are a kind of peptide aptamers. When the term mimotope was first coined by Mario Geysen in 1986, [1] it was used to describe peptides mimicking epitopes. However, this concept has been extended to refer peptide mimic of all types of binding sites.
Mimotope - an overview | ScienceDirect Topics
Mimotope (MP) is a peptide with specific amino acid sequence that mimics the epitope of an antigen and binds to the corresponding antibody. SMCs are classified as haptens in immunochemistry and their epitopes could be simulated by MPs.
多肽文库构建和筛选 - 知乎 - 知乎专栏
2022年6月12日 · 有些多肽虽然其序列与抗原的天然表位不同，但在结合抗体或配体时的方式是相同的，因此这种具有关键氨基酸残基的多肽称为模拟表位(mimotope)。 模拟表位的概念在 肽库 发展过程中起到了重要的推动作用。
Mimotope - an overview | ScienceDirect Topics
Mimotopes are peptide sequences that are capable of inducing immune responses by mimicking the structural features of a non-linear protein epitope or of a non-protein (e.g. carbohydrate) epitope structure. You might find these chapters and articles relevant to this topic. M.H.V. Van Regenmortel, in Encyclopedia of Virology (Third Edition), 2008.
Computational identification of antibody-binding epitopes from mimotope …
2024年2月22日 · A mimotope is a peptide that mimics the structure of an epitope, and which, in its most strict definition, causes an antibody response that is similar to the one elicited by the epitope (Geysen et al., 1986). An antibody for a given antigen is expected to recognize mimotopes which mimic the corresponding epitope.
MimoDB 2.0: a mimotope database and beyond - PMC
Mimotopes are peptides with affinities to given targets. They are readily obtained through biopanning against combinatorial peptide libraries constructed by phage display and other display technologies such as mRNA display, ribosome display, bacterial display and yeast display.
Mimotope vaccination – from allergy to cancer - PMC
2016年10月2日 · Mimotopes are peptides mimicking protein, carbohydrates or lipid epitopes and can be generated by phage display technology. When selected by antibodies, they represent exclusively B-cell epitopes and are devoid of antigen/allergen-specific T-cell epitopes.
Computational Methods for Mapping Mimotopes to Protein …
Mimotopes can mimic essential features of genuine epitopes and therefore their mapping to the antigen is a logical and essential step of the mimotope analysis. This page provides information on available methods for mimotope mapping, how to search the IEDB for mimotopes, and an example of a mimotope dataset and the results of its mapping, using ...
Mimotope | definition of mimotope by Medical dictionary
mimotope A novel peptide sequence which immunologically mimics an antigen’s epitope and has a 3-dimensional conformation, but not sequence homology, similar to the antigenic site. Mimotopes evoke an identical antibody response, and …
MimoDB 2.0: a mimotope database and beyond - PubMed
Mimotopes are peptides with affinities to given targets. They are readily obtained through biopanning against combinatorial peptide libraries constructed by phage display and other display technologies such as mRNA display, ribosome display, bacterial display and yeast display.
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